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ChemicalBook >> CAS DataBase List >>17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α

CAS No.
1027401-98-4
Chemical Name:
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α
Synonyms
17-TFM-PGF1α;DSVAWVBHUBDAPY-AHJNKEMKSA-N;17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α;17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α, CAS 1027401-98-4;7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pentyl)cyclopentyl)heptanoic acid;Cyclopentaneheptanoic acid, 3,5-dihydroxy-2-[(3R)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pentyl]-, (1R,2R,3R,5S)-
CBNumber:
CB92589959
Molecular Formula:
C24H35F3O5
Molecular Weight:
460.53
MDL Number:
MFCD05863947
MOL File:
1027401-98-4.mol
MSDS File:
SDS
Last updated:2026-05-28 05:57:03
Product description Number Pack Size Price
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 15895 1mg $71
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 15895 5mg $308
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 15895 10mg $547
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 15895 1mg $64
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 15895 5mg $280

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α Properties

solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml

SAFETY

Risk and Safety Statements

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15895 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 1027401-98-4 1mg $71 2026-04-30 Buy
Cayman Chemical 15895 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 1027401-98-4 5mg $308 2026-04-30 Buy
Cayman Chemical 15895 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 1027401-98-4 10mg $547 2026-04-30 Buy
Cayman Chemical 15895 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 1027401-98-4 1mg $64 2024-03-01 Buy
Cayman Chemical 15895 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α ≥98% 1027401-98-4 5mg $280 2024-03-01 Buy
Product number Packaging Price Buy
15895 1mg $71 Buy
15895 5mg $308 Buy
15895 10mg $547 Buy
15895 1mg $64 Buy
15895 5mg $280 Buy

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α Chemical Properties,Uses,Production

Description

A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2α derivatives have been approved for the treatment of glaucoma.1,2,3 These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.4 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1α (17-TFM-PGF1α) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1α is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding.5 As an ocular hypotensive agent, it is expected that 17-TFM-PGF1α would act very much like the free acid of latanoprost.

Uses

17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandin F1α (Compound 8) is a saturated prostaglandin analogue. 17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandin F1α has good affinity and receptor selectivity for human prostaglandin F receptor (hFP receptor) witn an EC50 of 85 nM[1].

Definition

ChEBI: 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1alpha is a prostanoid.

References

1. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of bimatoprost (Lumigan) Surv. Ophthalmol. 45(Suppl 4),S337-S345(2001).
2. Stjernschantz, J.W. From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture Invest. Ophthalmol. Vis. Sci. 42(6),1134-1145(2001).
3. Sorbera, L.A., and Castaer, J. Travoprost Drugs Future 25(1),41-45(2000).
4. Resul, B., Stjernschantz, J., No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents J. Med. Chem. 36,243-248(1993).
5. deLong, M.A., Amburgey, J., Taylor, C., et al. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues Bioorg. Med. Chem. Lett. 10,1519-1522(2000).

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α Preparation Products And Raw materials

Raw materials

Preparation Products

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α Suppliers

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Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
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Guangzhou Chuangze Biotechnology Co., Ltd. -- CHINA 6078 58
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α DSVAWVBHUBDAPY-AHJNKEMKSA-N Cyclopentaneheptanoic acid, 3,5-dihydroxy-2-[(3R)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pentyl]-, (1R,2R,3R,5S)- 7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pentyl)cyclopentyl)heptanoic acid 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α, CAS 1027401-98-4 17-TFM-PGF1α 1027401-98-4 C24H35F3O5
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