YS121
- CAS No.
- 916482-17-2
- Chemical Name:
- YS121
- Synonyms
- Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-;YS121;YS121 Exclusive;HVJBWTVMRIOTEL-UHFFFAOYSA-N
- CBNumber:
- CB92592892
- Molecular Formula:
- C20H26ClN3O2S
- Molecular Weight:
- 407.96
- MDL Number:
- MFCD18382121
- MOL File:
- 916482-17-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| YS-121 ≥98% | 13665 | 1mg | $61 |
| YS-121 ≥98% | 13665 | 5mg | $260 |
| YS-121 ≥98% | 13665 | 10mg | $462 |
| YS-121 ≥98% | 13665 | 25mg | $1006 |
| YS-121 ≥98% | 13665 | 1mg | $55 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
|
YS121 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13665 | YS-121 ≥98% | 916482-17-2 | 1mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 916482-17-2 | 5mg | $260 | 2026-04-30 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 916482-17-2 | 10mg | $462 | 2026-04-30 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 916482-17-2 | 25mg | $1006 | 2026-04-30 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 916482-17-2 | 1mg | $55 | 2024-03-01 | Buy |
YS121 Chemical Properties,Uses,Production
Description
Microsomal prostaglandin E2 synthase-
Uses
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].
Definition
ChEBI: Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]- is a medium-chain fatty acid.
References
[1] koeberle a, zettl h, greiner c, et al. pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of medicinal chemistry, 2008, 51(24): 8068-8076.
[2] mehrotra s, morimiya a, agarwal b, et al. microsomal prostaglandin e2 synthase‐1 in breast cancer: a potential target for therapy[j]. the journal of pathology, 2006, 208(3): 356-363.werz o, greiner c, koeberle a, et al. novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid[j]. journal of medicinal chemistry, 2008, 51(17): 5449-5453.koeberle a, rossi a, zettl h, et al. the molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2, 3-dimethylphenylamino) pyrimidin-2-ylthio) octanoic acid (ys121), a dual inhibitor of microsomal prostaglandin e2 synthase-1 and 5-lipoxygenase[j]. journal of pharmacology and experimental therapeutics, 2010, 332(3): 840-848.
YS121 Preparation Products And Raw materials
Raw materials
Preparation Products
YS121 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3504 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2826 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 19372819560 | Sales@ATKchemical.com | China | 9625 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24958 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29997 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
