OSI-754
- CAS No.
- 1190094-64-4
- Chemical Name:
- OSI-754
- Synonyms
- OSI-754;LNK 754;CP 609754;CP-609754(OS1754);CP-609754 (OSI754);CP-609754, 10 mM in DMSO;CP-609754 (OSI754, LNK 754);6-[(R)-(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one;2(1H)-Quinolinone, 6-[(R)-(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-;(R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one
- CBNumber:
- CB92628221
- Molecular Formula:
- C29H22ClN3O2
- Molecular Weight:
- 479.96
- MDL Number:
- MOL File:
- 1190094-64-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one | QXB09464 | 25mg | $832 |
| (R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one | QXB09464 | 50mg | $1331.5 |
| (R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one | QXB09464 | 100mg | $2131 |
| CP-609754 99.49% | CS-0006307 | 5mg | $152 |
| CP-609754 99.49% | CS-0006307 | 10mg | $255 |
| Boiling point | 702.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (208.35 mM; Need ultrasonic) |
| form | Solid |
| pka | 12.28±0.29(Predicted) |
| color | Off-white to yellow |
| InChI | InChI=1/C29H22ClN3O2/c1-4-19-6-5-7-20(14-19)24-16-28(34)33(3)26-13-10-22(15-25(24)26)29(35,27-17-31-18-32(27)2)21-8-11-23(30)12-9-21/h1,5-18,35H,2-3H3/t29-/s3 |
| InChIKey | JAHDAIPFBPPQHQ-NNFJEGBSNA-N |
| SMILES | N1(C)C2=C(C=C([C@@](C3=CC=C(Cl)C=C3)(O)C3N(C)C=NC=3)C=C2)C(C2=CC=CC(C#C)=C2)=CC1=O |&1:6,r| |
| NCI Dictionary of Cancer Terms | CP-609; 754 |
| FDA UNII | L0S47W9GPY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
OSI-754 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | QXB09464 | (R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one | 1190094-64-4 | 25mg | $832 | 2026-06-04 | Buy |
| Biosynth | QXB09464 | (R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one | 1190094-64-4 | 50mg | $1331.5 | 2026-06-04 | Buy |
| Biosynth | QXB09464 | (R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one | 1190094-64-4 | 100mg | $2131 | 2026-06-04 | Buy |
| ChemScene | CS-0006307 | CP-609754 99.49% | 1190094-64-4 | 5mg | $152 | 2026-06-04 | Buy |
| ChemScene | CS-0006307 | CP-609754 99.49% | 1190094-64-4 | 10mg | $255 | 2026-06-04 | Buy |
OSI-754 Chemical Properties,Uses,Production
Uses
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL[1]. CP-609754 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
CP-609754 (CP-609,754) has antitumor activity against 3T3 H-ras (61L) tumors in vivo[1].
With twice daily oral dosing of CP-609754, tumor regression is achieved with a dose of 100 mg/kg; the ED50 for tumor growth inhibition is 28 mg/kg[1].
With continuous i.p. infusion of CP-609754, tumor growth is inhibited by >50%, and tumor farnesyltransferase activity inhibited by >30% in mice in which the plasma concentration of CP-609754 is maintained above 118 ng/mL[1].
References
[1] Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35. DOI:10.1158/1078-0432.CCR-04-0901
OSI-754 Preparation Products And Raw materials
Raw materials
Preparation Products
OSI-754 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9941 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +86-0086-13720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Chengdu Henghui Pharm Tec Co. Ltd. | 13540674322 15828370308 | CHINA | 121 | 55 | |
| Chengdu Celes Technology Co., Ltd | 19982073091 | 2538834896@qq.com | China | 78 | 58 |
