ACK1-B19
- CAS No.
- 1234480-46-6
- Chemical Name:
- ACK1-B19
- Synonyms
- CS-2588;XMD8-87;ACK1-B19;XMD8-87 (ACK1-B19);XMD8-87, 10 mM in DMSO;XMD-8-87;XMD8 87;XMD 8 87;XMD8-87 (Ack1 inhibitor B19);Tyrosinase,Inhibitor,inhibit,XMD8 87,XMD-8-87,XMD887,XMD8-87;2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one;2-[[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
- CBNumber:
- CB92716117
- Molecular Formula:
- C24H27N7O2
- Molecular Weight:
- 445.52
- MDL Number:
- MFCD30742941
- MOL File:
- 1234480-46-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| XMD8-87 ≥98% | 23354 | 1mg | $36 |
| XMD8-87 ≥98% | 23354 | 5mg | $105 |
| XMD8-87 ≥98% | 23354 | 1mg | $32 |
| XMD8-87 ≥98% | 23354 | 5 mg | $95 |
| XMD8-87 ≥98% | 23354 | 10mg | $191 |
| Density | 1.283±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml |
| form | A crystalline solid |
| pka | 10.18±0.20(Predicted) |
| color | White to yellow |
| InChIKey | LGLHCXISMKHLIK-UHFFFAOYSA-N |
| SMILES | N1(CCN(CC1)c2cc(c(cc2)Nc3nc4[n](c5c([c]([nH]c4cn3)=O)cccc5)C)OC)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
ACK1-B19 price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23354 | XMD8-87 ≥98% | 1234480-46-6 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 23354 | XMD8-87 ≥98% | 1234480-46-6 | 5mg | $105 | 2026-04-30 | Buy |
| Cayman Chemical | 23354 | XMD8-87 ≥98% | 1234480-46-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23354 | XMD8-87 ≥98% | 1234480-46-6 | 5 mg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 23354 | XMD8-87 ≥98% | 1234480-46-6 | 10mg | $191 | 2023-01-06 | Buy |
ACK1-B19 Chemical Properties,Uses,Production
Description
XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM in HEK293T cells expressing human TNK2. It is selective for TNK2 over a panel of approximately 100 kinases with >90 and <50% inhibition for TNK2 and all other kinases tested, respectively. XMD8-87 inhibits growth of Ba/F3 cells expressing constitutively active mutant TNK2s (IC50s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC50 = >1 μM).
Uses
XMD8-87 is used in the studies of benzopyrimidodiazepinones as most selective and potent ERK5 inhibitor.
References
[1] MAXSON J E, ABEL M L, WANG J, et al. Data from Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis[C]//1 1. 2023: 0. DOI: 10.1158/0008-5472.c.6507081
ACK1-B19 Preparation Products And Raw materials
Raw materials
Preparation Products
ACK1-B19 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 | contact@trustwe.com | China | 5746 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10457 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9942 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
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