4-Bromo-2-fluoroanisole
- CAS No.
- 2357-52-0
- Chemical Name:
- 4-Bromo-2-fluoroanisole
- Synonyms
- 4-Bromo-2-fluoro-1-methoxybenzene;4-Bromo-2-fluoroanis;4-Cyano-fluoro phenol;Fluoro-4-bromoanisole;4-BROMO-2-FLUOROANISOLE;2-FLUORO-4-BROMOANISOLE;2-Fluoro-4-Bromo Anisol;4-Bromo-2-fluoroanisole98%;4-Bromo-2-fluoroanisole>4-Bromo-2-fluoroanisole 98%
- CBNumber:
- CB9282221
- Molecular Formula:
- C7H6BrFO
- Molecular Weight:
- 205.02
- MDL Number:
- MFCD00011710
- MOL File:
- 2357-52-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-2-fluoroanisole 97% | 293474 | 5g | $52.1 |
| 4-Bromo-2-fluoroanisole >98.0%(GC) | B1855 | 5g | $35 |
| 4-Bromo-2-fluoroanisole >98.0%(GC) | B1855 | 25g | $134 |
| 4-Bromo-2-fluoroanisole, min. 98% min.98% | 09-0056 | 25g | $92 |
| 4-Bromo-2-fluoroanisole, min. 98% min.98% | 09-0056 | 100g | $105 |
| More product size | |||
| Melting point | 16 °C |
|---|---|
| Boiling point | 84 °C/7 mmHg (lit.) |
| Density | 1.59 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 209 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Colorless to Light yellow |
| Specific Gravity | 1.590 |
| Water Solubility | insoluble |
| BRN | 3240714 |
| InChI | InChI=1S/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3 |
| InChIKey | DWNXGZBXFDNKOR-UHFFFAOYSA-N |
| SMILES | C1(OC)=CC=C(Br)C=C1F |
| CAS DataBase Reference | 2357-52-0(CAS DataBase Reference) |
| FDA UNII | F7J83Z8NHR |
| NIST Chemistry Reference | 4-Bromo-2-fluoroanisole(2357-52-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Bromo-2-fluoroanisole price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 293474 | 4-Bromo-2-fluoroanisole 97% | 2357-52-0 | 5g | $52.1 | 2023-06-20 | Buy |
| TCI Chemical | B1855 | 4-Bromo-2-fluoroanisole >98.0%(GC) | 2357-52-0 | 5g | $35 | 2026-04-30 | Buy |
| TCI Chemical | B1855 | 4-Bromo-2-fluoroanisole >98.0%(GC) | 2357-52-0 | 25g | $134 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0056 | 4-Bromo-2-fluoroanisole, min. 98% min.98% | 2357-52-0 | 25g | $92 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0056 | 4-Bromo-2-fluoroanisole, min. 98% min.98% | 2357-52-0 | 100g | $105 | 2026-04-30 | Buy |
4-Bromo-2-fluoroanisole Chemical Properties,Uses,Production
Chemical Properties
CLEAR VERY SLIGHTLY YELLOW LIQUID
Uses
4-Bromo-2-fluoroanisole has been used in the synthesis of:
- 1,4-bis[(3′-fluoro-4′-n alkoxyphenyl)ethynyl]benzenes with n=1-12
- 7-fluoro-6-methoxy-1-methyl-2-naphthaldehyde
- 5,7-difluoro-6-methoxy-1-methyl-2-naphthaldehyde
- liquid crystals with terminal difluoromethoxy group and backbone of phenylbicyclohexane
General Description
The IR and FT-IR spectra of 4-bromo-2-fluoroanisole have been investigated.
Synthesis
321-28-8
2357-52-0
(a) Synthesis of 2-fluoro-4-bromoanisole: Add 128 g (1.016 mol) of 2-fluoroanisole and 250 ml of chloroform to the reaction vessel. Under stirring conditions at room temperature, 177 g (1.106 mol) of bromine was slowly added dropwise for not less than 3 hours. Upon completion of the reaction, the reaction mixture was poured into dilute aqueous sodium hydroxide solution to separate the chloroform layer. The chloroform layer was subsequently washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. The solvent was removed by distillation and the residue was distilled under reduced pressure to give 2-fluoro-4-bromoanisole. The yield was 192 g (yield: 92.3%) and the boiling point was 107°-116°C (25-31 mmHg).
References
[1] Journal of Organic Chemistry, 2018, vol. 83, # 2, p. 930 - 938
[2] Patent: US5098602, 1992, A
[3] Helvetica Chimica Acta, 1984, vol. 67, p. 1572 - 1579
[4] Patent: US5397504, 1995, A
[5] Patent: US4997942, 1991, A
4-Bromo-2-fluoroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 | 1097@dideu.com | China | 3992 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
View Lastest Price from 4-Bromo-2-fluoroanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 4-Bromo-2-fluoroanisole
2357-52-0
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 4-Bromo-2-fluoroanisole
2357-52-0
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-12-24 | 4-Bromo-2-fluoroanisole
2357-52-0
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Bromo-2-fluoroanisole
2357-52-0
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Bromo-2-fluoroanisole
2357-52-0
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Bromo-2-fluoroanisole
2357-52-0
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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