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2-Bromo-4'-hydroxyacetophenone

2-Bromo-4'-hydroxyacetophenone structure

CAS No.: 2491-38-5

Chemical Name:: 2-Bromo-4'-hydroxyacetophenone

Synonyms: 2-bromo-1-(4-hydroxyphenyl)ethan-1-one;BHAP;BUSAN90;BUSAN1130;Butrol 1130;PTP INHIBITOR I;SHP-1 Inhibitor II;4-HYDROXYPHENACYL BR;4-(Bromoacetyl)phenol;(+)-alpha-isolupanine

CBNumber:: CB9306895

Molecular Formula:: C8H7BrO2

Molecular Weight:: 215.04

MDL Number:: MFCD00072424

MOL File:: 2491-38-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

Product description	Number	Pack Size	Price
2-bromo-4′-hydroxyacetophenone AldrichCPR	CDS013566	1G	$93.2
2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T)	B4115	5g	$31
2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T)	B4115	25g	$91
PTP Inhibitor I ≥98%	19766	50mg	$29
PTP Inhibitor I ≥98%	19766	100mg	$35
More product size

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2-Bromo-4'-hydroxyacetophenone Properties

Melting point	123-126°C
Boiling point	338.7±17.0 °C(Predicted)
Density	1.622±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	7.69±0.15(Predicted)
form	White powder
color	White to Light Beige
Sensitive	Lachrymatory
BRN	1865388
Stability	Hygroscopic
InChI	InChI=1S/C8H7BrO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,10H,5H2
InChIKey	LJYOFQHKEWTQRH-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(O)C=C1)CBr
FDA 21 CFR	176.170; 176.300
Indirect Additives used in Food Contact Substances	2-BROMO-4'-HYDROXYACETOPHENONE
CAS DataBase Reference	2491-38-5(CAS DataBase Reference)
FDA UNII	6H0QU4I6BA
EPA Substance Registry System	2-Bromo-4-hydroxyacetophenone (2491-38-5)
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H319

Precautionary statements

P264-P270-P280-P301+P312-P305+P351+P338-P337+P313

Hazard Codes

C,Xn

Risk Statements

22-36

Safety Statements

RIDADR

1760

WGK Germany

RTECS

AM5982000

Hazard Note

Corrosive/Lachrymatory/Keep Cold

HazardClass

PackingGroup

III

HS Code

2914500090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2

NFPA 704

	0
2		0

2-Bromo-4'-hydroxyacetophenone price More Price(86)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS013566	2-bromo-4′-hydroxyacetophenone AldrichCPR	2491-38-5	1G	$93.2	2026-04-30	Buy
TCI Chemical	B4115	2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T)	2491-38-5	5g	$31	2026-04-30	Buy
TCI Chemical	B4115	2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T)	2491-38-5	25g	$91	2026-04-30	Buy
Cayman Chemical	19766	PTP Inhibitor I ≥98%	2491-38-5	50mg	$29	2026-04-30	Buy
Cayman Chemical	19766	PTP Inhibitor I ≥98%	2491-38-5	100mg	$35	2026-04-30	Buy

Product number	Packaging	Price	Buy
CDS013566	1G	$93.2	Buy
B4115	5g	$31	Buy
B4115	25g	$91	Buy
19766	50mg	$29	Buy
19766	100mg	$35	Buy

2-Bromo-4'-hydroxyacetophenone Chemical Properties,Uses,Production

Description

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a K_i value of 43 μM and PTP1B with a K_i value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.

Chemical Properties

Pale Beige Solid

Uses

A covalent inhibitor of protein tyrosine phosphatases (PTPs)

Preparation

Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.

in vitro

in previous study, the corresponding values of ptp inhibitor i against ptp1b were determined to be ki of 42 μm, kinact of 0.57 min-1, and kinact/ki of 1.4*104 m-1 min-1, respectively. this study also showed that α-bromoacetophenone such as ptp inhibitor i could provide an effective, neutral py mimetic inhibitor of ptps. while perturbation of the electronic properties of the phenyl ring did not significantly improve its potency against ptps, attachment of a proper peptidyl moiety to the para position could improve both the potency and the selectivity substantially. in addition, since the covalent ptp inhibitor complex could be cleaved to regenerate the ptp activity photolytically, ptp inhibitor i might provide a novel class of photolytic switch for controlling cellular signaling processes [1].

References

[1] arabaci g, yi t, fu h, porter me, beebe kd, pei d. alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-activity relationship. bioorg med chem lett. 2002 nov 4;12(21):3047-50.

2-Bromo-4'-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

2-Bromo-2′-hydroxyacetophenone Bromoacetyl bromide Anisole

Preparation Products

4-Hydroxyphenylacetone 4-(BROMOACETYL)-PHENYL BENZOATE 2-aMino-1-(4-hydroxyphenyl)ethanone hydrochloride 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 4-QUINOXALIN-2-YLPHENOL

2-Bromo-4'-hydroxyacetophenone Suppliers

Global( 338)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3991	58
Tangshan Moneide Trading Co., Ltd.	+86-315-8309571 +8615633399667	sales@moneidechem.com	China	574	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Tangshan Moneide Trading Co., Ltd.	58
Richest Group Ltd	58
Antai Fine Chemical Technology Co.,Limited	58
TargetMol Chemicals Inc.	58

View Lastest Price from 2-Bromo-4'-hydroxyacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	2-Bromo-4'-hydroxyacetophenone 2491-38-5	$29.00		99.07%	10g	TargetMol Chemicals Inc.
2025-12-24	2-Bromo-4'-hydroxyacetophenone 2491-38-5	$2230.00	1KG	98.0%	1T	Shaanxi Dideu Medichem Co. Ltd
2025-04-04	2-Bromo-4'-hydroxyacetophenone 2491-38-5		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-Bromo-4'-hydroxyacetophenone
2491-38-5
$29.00
99.07%
TargetMol Chemicals Inc.

2-Bromo-4'-hydroxyacetophenone
2491-38-5
$2230.00
98.0%
Shaanxi Dideu Medichem Co. Ltd

2-Bromo-4'-hydroxyacetophenone
2491-38-5
98%
Henan Aochuang Chemical Co.,Ltd.

2-Bromo-4'-hydroxyacetophenone Spectrum

2-Bromo-4'-hydroxyacetophenone(2491-38-5)¹HNMR

2491-38-5(2-Bromo-4'-hydroxyacetophenone)Related Search:

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3'-Bromoacetophenone 2',6'-Dihydroxyacetophenone 3-Bromoanisole 2,4-Dihydroxyacetophenone 4'-Methylacetophenone

4'-Hydroxyacetophenone L-PICEIN Bromine

1of4

PTP INHIBITOR I PROTEIN TYROSINE PHOSPHATASE INHIBITOR I ALPHA-BROMO-4-HYDROXYACETOPHENONE 4-HYDROXYPHENACYL BR 4-HYDROXYPHENACYL BROMIDE 2-BROMO-1-(4-HYDROXY-PHENYL)-ETHANONE 2'-BROMO-4'-HYDROXYACETOPHENONE 4-Hydroxy α-Bromoacetophenone 4-HYDROXY A-BROMOACETOPHENONE Ethanone, 2-bromo-1-(4-hydroxyphenyl)- A-BROMO-4-HYDROXY ACETOPHENONE 1-(4-hydroxyphenyl)-2-bromoethanone BROMOHYDROXYACETOPHENONE BUSAN1130 BUSAN90 2-Brom-1-(4-hydroxyphenyl)ethan-1-on α-Bromo-4-hydroxyacetophenone 4-Hydroxy-alpha-bromoacetophenone 2-Bromo-4-Hydroxyacetophenone98% Alpha broMine generation of hydroxy acetophenone α-broMo p-hydroxyacetophenone 4-(Bromoacetyl)phenol p-Hydroxy α-Bromoacetophenone 2-Bromo-4'-hydroxyacetophenone, 2-Bromo-1-(4-hydroxyphenyl)ethan-1-one Aipha-BroMo-4-hydroxyacetophenone Butrol 1130 p-Hydroxyphenacyl BroMide 4-Hydroxyphenacyl bromide 97% PTP Inhibitor I - CAS 2491-38-5 - Calbiochem 2-Bromo-4'-hydroxyacetophenone > SHP-1 Inhibitor II 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) BHAP 2-Bromo-4'-hydroxyacetophenone Cyclohexane Impurity 5 Isavuconazole Impurity N16 2-Bromo-4''-hydroxyacetophenone 2-Bromo-4''-hydroxyacetophenone, 10 mM in DMSO (+)-alpha-isolupanine 2-bromo-1-(4-hydroxyphenyl)ethan-1-one 2491-38-5 Aromatics Inhibitors Aromatic Acetophenones & Derivatives (substituted)

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