2-Hydroxy-5-trifluoromethylpyridine
- CAS No.
- 33252-63-0
- Chemical Name:
- 2-Hydroxy-5-trifluoromethylpyridine
- Synonyms
- 5-(TRIFLUOROMETHYL)-2-PYRIDINOL;2-Hydroxy-5-(t;BUTTPARK 24\01-67;Fampridine Impurity 216;5-Trifluoromethyl-Pyridin-2-;Hydroxy-5-(trifluoroMethyl)pyr;5-Trifluoromethyl-pyridin-2-ol;5-(Trifluoromethyl)-2-pyridone;5-(Trifluoromethyl)pyridin-2-one;5-(Trifluoromethyl)-2-pyridinone
- CBNumber:
- CB9321836
- Molecular Formula:
- C6H4F3NO
- Molecular Weight:
- 163.1
- MDL Number:
- MFCD00042315
- MOL File:
- 33252-63-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Hydroxy-5-(trifluoromethyl)pyridine 97% | 442801 | 5G | $71.6 |
| 5-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T) | T2539 | 5g | $45 |
| 5-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T) | T2539 | 25g | $131 |
| 2-Hydroxy-5-(trifluoromethyl)pyridine | H9117-97G | 10g | $403 |
| 2-Hydroxy-5-(trifluoromethyl)pyridine | TRC-H971570-5G | 5g | $77 |
| More product size | |||
| Melting point | 145-149 °C (lit.) |
|---|---|
| Boiling point | 221.2±40.0 °C(Predicted) |
| Density | 1.398±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Soluble), Ethanol (Sparingly), Methanol (Sightly) |
| pka | 9.55±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| InChI | InChI=1S/C6H4F3NO/c7-6(8,9)4-1-2-5(11)10-3-4/h1-3H,(H,10,11) |
| InChIKey | BYRJSCNPUHYZQE-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(C(F)(F)F)C=C1 |
| CAS DataBase Reference | 33252-63-0(CAS DataBase Reference) |
| FDA UNII | 1CCP81H07B |
| EPA Substance Registry System | 2(1H)-Pyridinone, 5-(trifluoromethyl)- (33252-63-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-65-20/21/22-20/21 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2-Hydroxy-5-trifluoromethylpyridine price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 442801 | 2-Hydroxy-5-(trifluoromethyl)pyridine 97% | 33252-63-0 | 5G | $71.6 | 2026-04-30 | Buy |
| TCI Chemical | T2539 | 5-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T) | 33252-63-0 | 5g | $45 | 2026-04-30 | Buy |
| TCI Chemical | T2539 | 5-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T) | 33252-63-0 | 25g | $131 | 2026-04-30 | Buy |
| Usbiological | H9117-97G | 2-Hydroxy-5-(trifluoromethyl)pyridine | 10g | $403 | 2026-06-03 | Buy | |
| TRC | TRC-H971570-5G | 2-Hydroxy-5-(trifluoromethyl)pyridine | 33252-63-0 | 5g | $77 | 2026-06-03 | Buy |
2-Hydroxy-5-trifluoromethylpyridine Chemical Properties,Uses,Production
Chemical Properties
Yellow to brown powder
Uses
2-Hydroxy-5-(trifluoromethyl)pyridine (cas# 33252-63-0) is a compound useful in organic synthesis.
General Description
2-Hydroxy-5-(trifluoromethyl)pyridine, a pyridine derivative, is a heterocyclic building block. They have useful applications in catalysis, drug design, molecular recognition, and natural product synthesis.
Synthesis
5006-66-6
33252-63-0
General procedure for the synthesis of 2-hydroxy-5-trifluoromethylpyridine from 6-hydroxynicotinic acid: 6-hydroxynicotinic acid (18.2 g, 0.13 mol), anhydrous hydrofluoric acid (2.6 mL, 0.13 mol, ≥95 wt%) and sulfur tetrafluoride (42.1 g, 0.39 mol) were added to a stainless steel pressure tank. The mixture was heated to 100 °C and reacted at 0.15 MPa pressure for 12 hours. The gaseous product generated during the reaction was treated by an exhaust gas absorption unit. Upon completion of the reaction, the remaining product was transferred to a polytetrafluoroethylene vessel and heated to 40°C to remove residual hydrogen fluoride. Subsequently, the product was dissolved in 150 mL of water and the pH was adjusted to 6.8-7.2 with saturated sodium carbonate solution. the aqueous phase was extracted with chloroform, and the organic phases were combined and dried. After filtration and drying, 2-hydroxy-5-trifluoromethylpyridine (15.3 g, 0.094 mol) was obtained in 72% yield.
References
[1] Patent: CN102875453, 2016, B. Location in patent: Paragraph 0023
2-Hydroxy-5-trifluoromethylpyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 2-Hydroxy-5-trifluoromethylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Hydroxy-5-trifluoromethylpyridine
33252-63-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-09-25 | 2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE
33252-63-0
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2019-07-06 | 2-Hydroxy-5-trifluoromethylpyridine
33252-63-0
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 2-Hydroxy-5-trifluoromethylpyridine
33252-63-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE
33252-63-0
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2-Hydroxy-5-trifluoromethylpyridine
33252-63-0
- $1.00
- 98%
- Career Henan Chemical Co
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