3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
![3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Structure](CAS/GIF/112192-04-8.gif)
- CAS No.
- 112192-04-8
- Chemical Name:
- 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
- Synonyms
- Roxindole;RoxindoleHCl;Roxindole [inn];ROXINDOLE HYDROCHLORIDE;1H-Indol-5-ol, 3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-;3-[4-[(3,6-Dihydro-4-phenylpyridin)-1(2H)-yl]butyl]-1H-indol-5-ol;3-[4-(3,6-Dihydro-4-phenylpyridine-1(2H)-yl)butyl]-1H-indole-5-ol;3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
- CBNumber:
- CB9330973
- Molecular Formula:
- C23H26N2O
- Molecular Weight:
- 346.47
- MDL Number:
- MFCD04038810
- MOL File:
- 112192-04-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Roxindole 99.08%(Mayvarybetweenbatches) | orb1701643 | 1mg | $340 |
| Roxindole 99.08%(Mayvarybetweenbatches) | orb1701643 | 5mg | $770 |
| Roxindole 99.08%(Mayvarybetweenbatches) | orb1701643 | 10mg | $1030 |
| Roxindole 99.08%(Mayvarybetweenbatches) | orb1701643 | 25mg | $1560 |
| Roxindole 99.08%(Mayvarybetweenbatches) | orb1701643 | 50mg | $2020 |
| Melting point | >165°C (dec.) |
|---|---|
| Boiling point | 575.7±50.0 °C(Predicted) |
| Density | 1.173±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | DMSO (Slightly), Water (Slightly) |
| pka | 10.15±0.40(Predicted) |
| form | Solid |
| color | Pale Beige to Light Beige |
| Stability | Hygroscopic |
| FDA UNII | 43227SMS0O |
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb1701643 | Roxindole 99.08%(Mayvarybetweenbatches) | 112192-04-8 | 1mg | $340 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1701643 | Roxindole 99.08%(Mayvarybetweenbatches) | 112192-04-8 | 5mg | $770 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1701643 | Roxindole 99.08%(Mayvarybetweenbatches) | 112192-04-8 | 10mg | $1030 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1701643 | Roxindole 99.08%(Mayvarybetweenbatches) | 112192-04-8 | 25mg | $1560 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1701643 | Roxindole 99.08%(Mayvarybetweenbatches) | 112192-04-8 | 50mg | $2020 | 2026-05-06 | Buy |
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
Roxindole Hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist.
Definition
ChEBI: Roxindole is a member of indoles. It has a role as an alpha-adrenergic antagonist and a serotonergic drug.
Biological Activity
Dopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .
in vivo
Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[1].
Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3].
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44909 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24957 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
