ADX-102 (NS-2)
- CAS No.
- 916056-79-6
- Chemical Name:
- ADX-102 (NS-2)
- Synonyms
- Reproxalap;2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol;Reproxzlap;ADX-102 (NS-2);ADX-102 (Reproxalap;Reproxalap (ADX-102);Reproxalap, 10 mM in DMSO;2-Quinolinemethanol,3-amino-6-chloro-α,α-dimethyl-;2-Quinolinemethanol, 3-amino-6-chloro-α,α-dimethyl-;Inhibitor,NS 2,Reproxalap,ADX 102,ADX102,inhibit,NS2
- CBNumber:
- CB93358334
- Molecular Formula:
- C12H13ClN2O
- Molecular Weight:
- 236.7
- MDL Number:
- MFCD28502442
- MOL File:
- 916056-79-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Reproxalap 98.49% | CS-0027443 | 10mg | $65 |
| Reproxalap 98.49% | CS-0027443 | 25mg | $135 |
| Reproxalap 98.49% | CS-0027443 | 50mg | $227 |
| Reproxalap 98.49% | CS-0027443 | 100mg | $368 |
| Reproxalap 98.49% | CS-0027443 | 10mg | $65 |
| Boiling point | 410.5±40.0 °C(Predicted) |
|---|---|
| Density | 1.324±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (422.48 mM; Need ultrasonic) |
| form | Solid |
| pka | 13.07±0.29(Predicted) |
| color | Light yellow to yellow |
| InChI | InChI=1S/C12H13ClN2O/c1-12(2,16)11-9(14)6-7-5-8(13)3-4-10(7)15-11/h3-6,16H,14H2,1-2H3 |
| InChIKey | GUHFUVLKYSQIOQ-UHFFFAOYSA-N |
| SMILES | CC(C1=C(N)C=C2C(=N1)C=CC(Cl)=C2)(O)C |
| FDA UNII | F0GIZ22IJH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
ADX-102 (NS-2) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0027443 | Reproxalap 98.49% | 916056-79-6 | 10mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-0027443 | Reproxalap 98.49% | 916056-79-6 | 25mg | $135 | 2026-06-04 | Buy |
| ChemScene | CS-0027443 | Reproxalap 98.49% | 916056-79-6 | 50mg | $227 | 2026-06-04 | Buy |
| ChemScene | CS-0027443 | Reproxalap 98.49% | 916056-79-6 | 100mg | $368 | 2026-06-04 | Buy |
| ChemScene | CS-0027443 | Reproxalap 98.49% | 916056-79-6 | 10mg | $65 | 2026-06-04 | Buy |
ADX-102 (NS-2) Chemical Properties,Uses,Production
Uses
Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks caspase 3/7 activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis[1][2][3][4][5].
in vivo
Reproxalap (30-100 mg/kg, once or twice a day) shows a dose-dependent reduction in pain-related behaviors in acute pain models[3].
Reproxalap (10 mg/kg, intraperitoneal injection, single dose) significantly reduces the formation of N-retinyl-phosphatidylethanolamine (A2E) in the retinas of mice with macular degeneration[5].
Reproxalap (25-50 μg, IVT, injected in five doses after LPS (HY-D1056) induction) can improve eye scores in uveitis rats[5].
| Animal Model: | Carrageenaninduced and Complete Freund’s Adjuvant (CFA)-induced models in mice[3] |
| Dosage: | 30, 100 mg/kg; once a day or twice a day |
| Administration: | |
| Result: | Was effective in thermal hyperalgesia in the CFA-induced model at both 100 mg/kg QD and BID doses; in the carrageenan-induced model, and was effective at 30 mg/kg BID and 100 mg/kg BID doses. Was effective in mechanical allodynia only in the CFA-induced model at a 100 mg/kg BID dose; in the carrageenan-induced model, was not effective. Had a mild effect on swelling in the CFA-induced model at 30 mg/kg BID and 100 mg/kg BID doses; in the carrageenan-induced model, had a mild effect at a 100 mg/kg QD dose. |
| Animal Model: | A mouse knockout model (abcr-/-) of macular degeneration (MD) [5] |
| Dosage: | 10 mg/kg; single dose |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced the formation of N-retinylidene-N-retinylethanolamine (A2E) in the retina by 71% without affecting dark adaptation or body weight. |
| Animal Model: | A rat model of lipopolysaccharide (LPS)-induced uveitis[5] |
| Dosage: | 10 mg/kg 50 μg at hours 1, 3, 7, 10 and 17, after LPS induction, or injection 25 μg at 1 hour after LPS induction |
| Administration: | Intravitreal (IVT) |
| Result: | Improved the eye examination scores, enhancing the retinal-choroidal ratings. |
IC 50
PKCα; Caspase 3; Caspase-7
References
[1] Ochoa CA, et al. Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury. Biomolecules. 2022 Mar 2;12(3):393. DOI:10.3390/biom12030393
[2] Rizzo WB, et al. Sjgren-Larsson syndrome: A biochemical rationale for using aldehyde-reactive therapeutic agents. Mol Genet Metab Rep. 2021 Dec 23;30:100839. DOI:10.1016/j.ymgmr.2021.100839
[3] Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain.
[4] Reproxalap Phase 2b Dry Eye Disease Results.
[5] Susan G. Macdonald, Ph.D., et al. Novel Small Molecule Aldehyde Sequestering Agents Demonstrate Broad Therapeutic Potential for Ocular Inflammation.
ADX-102 (NS-2) Preparation Products And Raw materials
Raw materials
Preparation Products
ADX-102 (NS-2) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Guangzhou CATO Research Chemicals Inc. | +86-020-81960175-617 +8615602392859 | Intermediate@cato-chem.com | China | 3858 | 58 |
| Taizhou Zhongzhi Biotechnology Co., Ltd | zhongzhipharma@126.c | zhongzhipharma@126.com | China | 9729 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3504 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4849 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6355 | 58 | |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9625 | 58 |
View Lastest Price from ADX-102 (NS-2) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Reproxalap
916056-79-6
|
$33.00-98.00 | 99.89% | 10g | TargetMol Chemicals Inc. |
-
- Reproxalap
916056-79-6
- $33.00-98.00
- 99.89%
- TargetMol Chemicals Inc.
