Source

Rabbit

Reactivity

Human

Background

The p53 family member, p73, exists in multiple isoforms/splice variants and can induce apoptosis and cell cycle arrest in response to DNA damage via its activity as a transcription regulator. Upon DNA damage, p73 is phosphorylated at Tyr99 by c-Abl, causing translocation to the nuclear matrix. DNA damage-induced acetylation of p73 at Lys321 by the acetyltransferase p300 has also been reported to enhance transcription of genes including that of p53AIP1. Another report, however, indicates that p300 does not acetylate full-length p73 in vivo.

References

[1] Kaghad, M. et al. (1997) Cell 90, 809-19.
[2] Jost, C.A. et al. (1997) Nature 389, 191-4.
[3] De Laurenzi, V.D. et al. (1999) Cell Death Differ 6, 389-90.
[4] Ben-Yehoyada, M. et al. (2003) J Biol Chem 278, 34475-82.
[5] Costanzo, A. et al. (2002) Mol Cell 9, 175-86.
[6] Zeng, X. et al. (2001) J Biol Chem 276, 48-52.

Raw materials

Preparation Products