Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Lamins are nuclear membrane structural components that are important in maintaining normal cell functions, such as cell cycle control, DNA replication, and chromatin organization. Lamins have been subdivided into types A and B. Type-A lamins consist of lamin A and C, which arise from alternative splicing of the lamin A gene LMNA. Lamin A and C are cleaved by caspases into large and small fragments, which can be used as markers for apoptosis. Type-B lamins consist of lamin B1 and B2, encoded by separate genes. Lamin B1 is also cleaved by caspases during apoptosis. Research studies have shown that duplication of the lamin B1 gene LMNB1 is correlated with pathogenesis of the neurological disorder adult-onset leukodystrophy.

References

[1] Gruenbaum, Y. et al. (2000) J Struct Biol 129, 313-23.
[2] Goldberg, M. et al. (1999) Crit Rev Eukaryot Gene Expr 9, 285-93.
[3] Yabuki, M. et al. (1999) Physiol Chem Phys Med NMR 31, 77-84.
[4] Rao, L. et al. (1996) J Cell Biol 135, 1441-55.
[5] Orth, K. et al. (1996) J Biol Chem 271, 16443-6.
[6] Biamonti, G. et al. (1992) Mol Cell Biol 12, 3499-506.
[7] Lin, F. and Worman, H.J. (1995) Genomics 27, 230-6.
[8] Pollard, K.M. et al. (1990) Mol Cell Biol 10, 2164-75.
[9] Chandler, J.M. et al. (1997) Biochem J 322 ( Pt 1), 19-23.
[10] Padiath, Q.S. et al. (2006) Nat Genet 38, 1114-23.

Raw materials

Preparation Products