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Phospho-VEGF Receptor 2 (Tyr951) Antibody

CAS No.
Chemical Name:
Phospho-VEGF Receptor 2 (Tyr951) Antibody
Synonyms
Phospho-VEGF Receptor 2 (Tyr951) Antibody
CBNumber:
CB95748504
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Phospho-VEGF Receptor 2 (Tyr951) Antibody Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human;Mouse

Background

Vascular endothelial growth factor receptor 2 is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated. Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain and in the tyrosine kinase catalytic domain. Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2. Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb. Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo.

References

[1] Meyer, M. et al. (1999) EMBO J 18, 363-74.
[2] Dougher-Vermazen, M. et al. (1994) Biochem Biophys Res Commun 205, 728-38.
[3] Kroll, J. and Waltenberger, J. (1997) J Biol Chem 272, 32521-7.
[4] Takahashi, T. et al. (2001) EMBO J 20, 2768-78.
[5] Holmqvist, K. et al. (2004) J Biol Chem 279, 22267-75.
[6] Karkkainen, M.J. and Petrova, T.V. (2000) Oncogene 19, 5598-605.
[7] Rahimi, N. et al. (2000) J Biol Chem 275, 16986-92.
[8] Claesson-Welsh, L. (2003) Biochem Soc Trans 31, 20-4.

Phospho-VEGF Receptor 2 (Tyr951) Antibody Preparation Products And Raw materials

Raw materials

Preparation Products

Phospho-VEGF Receptor 2 (Tyr951) Antibody Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25021 58
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Guangzhou Jinling Biotechnology Co., Ltd. 15017560539 CHINA 6140 58
Hangzhou Novas Biotechnology Co., Ltd. 15264006066 CHINA 1844 58
Beijing Boning Biotechnology Co., Ltd. 010-67500625 18210120938 384669408@qq.com China 6395 58
Shanghai Tuoran Biotechnology Co., Ltd. 18621916228 CHINA 5067 58
Guangzhou Bingheng Biotechnology Co., Ltd. 13631342304 CHINA 6888 58
Phospho-VEGF Receptor 2 (Tyr951) Antibody
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