Source

Rabbit

Reactivity

Human

Background

The IL-17 family of cytokines consists of IL-17A-F, and their receptors include IL-17RA-RE. IL-17 cytokines are produced by a variety of cell types including the Th17 subset of CD4+ T cells, as well as subsets of γδ T cells, NK cells, and NKT cells. IL-17A and IL-17F, the most well-studied of the IL-17 cytokines, contribute to fungal and bacterial immunity by inducing expression of proinflammatory cytokines, chemokines, and antimicrobial peptides. In addition, IL-17A contributes to the pathogenesis of several autoimmune diseases. IL-17E promotes Th2 cell responses. The roles of IL-17B, IL-17C, and IL-17D are less clear, however these family members also appear to have the capacity to induce proinflammatory cytokines. IL-17 receptors have an extracellular domain, a transmembrane domain, and a SEFIR domain. They are believed to signal as homodimers, heterodimers, or multimers through their SEFIR domain by recruiting the SEFIR domain-containing adaptor Act1. Unlike most cytokines that signal through Jak/STAT pathways, IL-17 signaling results in NF-κB activation.IL-17RA associates with IL-17RC to mediate signaling by homodimers and heterodimers of IL-17A and IL-17F. IL-17RA is broadly expressed with highest expression in hematopoietic cells.

References

[1] Gaffen, S.L. (2009) Nat Rev Immunol 9, 556-67.
[2] Iwakura, Y. et al. (2011) Immunity 34, 149-62.
[3] Hu, Y. et al. (2011) Ann N Y Acad Sci 1217, 60-76.
[4] Fort, M.M. et al. (2001) Immunity 15, 985-95.
[5] Yamaguchi, Y. et al. (2007) J Immunol 179, 7128-36.
[6] Li, H. et al. (2000) Proc Natl Acad Sci U S A 97, 773-8.
[7] Chang, S.H. et al. (2006) J Biol Chem 281, 35603-7.
[8] Shalom-Barak, T. et al. (1998) J Biol Chem 273, 27467-73.
[9] Toy, D. et al. (2006) J Immunol 177, 36-9.
[10] Wright, J.F. et al. (2008) J Immunol 181, 2799-805.

Raw materials

Preparation Products