Fmoc-Asp-OAll
- CAS No.
- 144120-53-6
- Chemical Name:
- Fmoc-Asp-OAll
- Synonyms
- Fmoc-L-Asp(OAll)-OH;FMOC-L-ASP-OALL;(S)-3-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-4-(allyloxy)-4-oxobutanoic acid;FMOC-ASP-OAL;FMOC-ASP-OAI;FMOC-ASP-OALL;H-Fmoc-AspOAll;Fmoc-L-ASp(OAIl)-0H;FMOC-ASP-ALLYL ESTER;Icatibant Impurity 21
- CBNumber:
- CB9686568
- Molecular Formula:
- C22H21NO6
- Molecular Weight:
- 395.41
- MDL Number:
- MFCD00467715
- MOL File:
- 144120-53-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Fmoc-Asp-OAll Novabiochem? | 8.52072 | 1g | $91.9 |
| Fmoc-Asp-OAll Novabiochem? | 8.52072 | 5G | $369 |
| Fmoc-Asp-OAll ≥97.0% (HPLC) | 47578 | 5G | $617 |
| 1-Allyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate >98.0%(HPLC)(T) | A2894 | 1g | $87 |
| 1-Allyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate >98.0%(HPLC)(T) | A2894 | 5g | $347 |
| More product size | |||
| Melting point | 131.0 to 135.0 °C |
|---|---|
| Boiling point | 634.8±55.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in water or 1% acetic acid |
| pka | 4.09±0.19(Predicted) |
| form | Powder |
| color | White |
| optical activity | [α]20/D 24.5±2°, c = 1% in DMF |
| BRN | 5460108 |
| Major Application | peptide synthesis |
| InChI | 1S/C22H21NO6/c1-2-11-28-21(26)19(12-20(24)25)23-22(27)29-13-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h2-10,18-19H,1,11-13H2,(H,23,27)(H,24,25)/t19-/m0/s1 |
| InChIKey | ZJMVIWUCCRKNHY-IBGZPJMESA-N |
| SMILES | OC(=O)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(=O)OCC=C |
| CAS DataBase Reference | 144120-53-6(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| HazardClass | IRRITANT |
| Storage Class | 11 - Combustible Solids |
Fmoc-Asp-OAll price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52072 | Fmoc-Asp-OAll Novabiochem? | 144120-53-6 | 1g | $91.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52072 | Fmoc-Asp-OAll Novabiochem? | 144120-53-6 | 5G | $369 | 2026-04-30 | Buy |
| Sigma-Aldrich | 47578 | Fmoc-Asp-OAll ≥97.0% (HPLC) | 144120-53-6 | 5G | $617 | 2026-04-30 | Buy |
| TCI Chemical | A2894 | 1-Allyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate >98.0%(HPLC)(T) | 144120-53-6 | 1g | $87 | 2026-04-30 | Buy |
| TCI Chemical | A2894 | 1-Allyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate >98.0%(HPLC)(T) | 144120-53-6 | 5g | $347 | 2026-04-30 | Buy |
Fmoc-Asp-OAll Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
Fmoc-asp-oall is an intermediate used in the synthesis of some biologically active molecules.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
![L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(1,1-dimethylethyl) 1-(2-propen-1-yl) ester](/CAS/20200515/GIF/144120-52-5.gif)
144120-52-5
144120-53-6
Procedure for the synthesis of Nα-Fmoc-L-aspartic acid α-allyl ester: Nα-Fmoc-L-aspartic acid (OH) allyl ester (0.77 g; 1.94 mmol) was dissolved in a mixture of dichloromethane (DCM, 4 ml) and trifluoroacetic acid (TFA, 2 ml), and the reaction was stirred for 1 h at room temperature. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The resulting solid was dissolved in saturated aqueous sodium bicarbonate (NaHCO3) solution and washed with ether. Subsequently, it was acidified to pH 2 with 5% hydrochloric acid (HCl) to produce a white precipitate. It was extracted twice with ethyl acetate (EE) and the organic phases were combined. The organic phase was washed with acidified water (HCl, pH 1), dried over anhydrous sodium sulfate (Na2SO4), and evaporated under reduced pressure to afford the target product Nα-Fmoc-L-aspartic acid α-allyl ester (87% yield). The product was structurally confirmed by 1H NMR (250 MHz, DMSO-d6) and 13C NMR (75 MHz, CDCl3), and the purity was verified by ESI-MS (m + Na: 418.1) and HPLC (Rt: 22.0 min, gradient 10-100%).
References
[1] Tetrahedron Letters, 1992, vol. 33, # 32, p. 4557 - 4560
[2] Chemical Communications, 2011, vol. 47, # 39, p. 10939 - 10941
[3] Carbohydrate Research, 2007, vol. 342, # 3-4, p. 541 - 557
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 21, p. 7648 - 7662
[5] Patent: US2014/39153, 2014, A1. Location in patent: Paragraph 0150; 0151; 0152
Fmoc-Asp-OAll Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1103 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Sichuan Jiaying Lai Technology Co.,LTD | 18716376478 | ycling@enlaibio.com | CHINA | 302 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from Fmoc-Asp-OAll manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | Fmoc-L-Asp-OAll
144120-53-6
|
1kg | 98% | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-04-22 | Fmoc-Asp-OAll
144120-53-6
|
$29.00 | 98.43% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-25 | Fmoc-Asp-OAll
144120-53-6
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd |
-
- Fmoc-L-Asp-OAll
144120-53-6
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Fmoc-Asp-OAll
144120-53-6
- $29.00
- 98.43%
- TargetMol Chemicals Inc.
-
- Fmoc-Asp-OAll
144120-53-6
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
