2-Hydrazinopyrazine
- CAS No.
- 54608-52-5
- Chemical Name:
- 2-Hydrazinopyrazine
- Synonyms
- 2-Hydrazinylpyrazine;2-HYDRAZINOPYRAZINE;SELI-007;Hydrazinopyrazine;Pyrazinylhydrazine;2-Hydrazinylpyrazin;3-Hydrazine pyrazine;2-hydrazineylpyrazine;PYRAZIN-2-YL-HYDRAZINE;1-(pyrazin-2-ylydrazine
- CBNumber:
- CB9692578
- Molecular Formula:
- C4H6N4
- Molecular Weight:
- 110.12
- MDL Number:
- MFCD04114555
- MOL File:
- 54608-52-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-HYDRAZINYLPYRAZINE 95% | 62974 | 25G | $84 |
| 2-HYDRAZINYLPYRAZINE 95% | 62974 | 100G | $279 |
| 2-HYDRAZINYLPYRAZINE 95% | 62974 | 250G | $499 |
| Pyrazin-2-yl-hydrazine | FP50986 | 2g | $150 |
| Pyrazin-2-yl-hydrazine | FP50986 | 1g | $150 |
| More product size | |||
| Melting point | 109-113℃ |
|---|---|
| Boiling point | 246.3±23.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| pka | 5.10±0.20(Predicted) |
| form | Solid |
| color | Yellow |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C4H6N4/c5-8-4-3-6-1-2-7-4/h1-3H,5H2,(H,7,8) |
| InChIKey | IVRLZJDPKUSDCF-UHFFFAOYSA-N |
| SMILES | C1(NN)=NC=CN=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P405-P501a-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41-36/37/38 | |||||||||
| Safety Statements | 26-39-36/37/39 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
2-Hydrazinopyrazine price More Price(98)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 62974 | 2-HYDRAZINYLPYRAZINE 95% | 54608-52-5 | 25G | $84 | 2026-04-30 | Buy |
| AstaTech | 62974 | 2-HYDRAZINYLPYRAZINE 95% | 54608-52-5 | 100G | $279 | 2026-04-30 | Buy |
| AstaTech | 62974 | 2-HYDRAZINYLPYRAZINE 95% | 54608-52-5 | 250G | $499 | 2026-04-30 | Buy |
| Biosynth | FP50986 | Pyrazin-2-yl-hydrazine | 54608-52-5 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FP50986 | Pyrazin-2-yl-hydrazine | 54608-52-5 | 1g | $150 | 2026-06-04 | Buy |
2-Hydrazinopyrazine Chemical Properties,Uses,Production
Chemical Properties
Pale yellow solid
Uses
Triazolo[4,3-a]pyrazine 7-oxide, 3-β-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine, monohydrazones of pyridine, pyrazine, phenylglyoxal were synthesised from 2-Hydrazinopyrazine.
Application
2-Hydrazinopyrazine is used as a reagent in the synthesis of Sitagliptin (S491000, H3PO4) and its analogs. Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor that has recently been approved for the therapy of type II diabetes.
Synthesis
14508-49-7
54608-52-5
Step 1: Synthesis of pyrazine-2-hydrazine from 2-chloropyrazine. 2-Chloropyrazine (2.0 g, 17.5 mmol) was slowly added dropwise to 35% aqueous hydrazine hydrate (25.8 g, 97.8 mmol) at 63-65°C, and the rate of acceleration of the dropwise addition was strictly controlled so as to maintain the temperature of the reaction not exceeding 65°C. After the dropwise addition was completed, the reaction mixture was heated further up to 65°C and kept at this temperature. The reaction mixture was stirred overnight and cooled to room temperature. The solvent was removed by distillation under reduced pressure to give the product pyrazine-2-hydrazine (1.5 g, 75% yield) as a yellow powder. Mass spectrometry (ESI) analysis: calculated value C4H6N4[M]: 110.1; measured value: 111.4 [M+H]+.1H NMR (400 MHz, CD3OD) δ 8.10 (d, J=1.6 Hz, 1H), 8.00 (dd, J=3.2,1.6 Hz, 1H), 7.73 (d, J=3.2 Hz, 1H).
References
[1] Patent: WO2016/100349, 2016, A2. Location in patent: Paragraph 0204
[2] Letters in Organic Chemistry, 2013, vol. 10, # 5, p. 348 - 352
[3] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00198
[4] Patent: US2014/228361, 2014, A1. Location in patent: Paragraph 0279-0280
[5] Patent: CN106749262, 2017, A. Location in patent: Paragraph 0035
2-Hydrazinopyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 | gjpu@astatech.com.cn | China | 308 | 58 |
| Shandong Liteng Biotechnology Co. , Ltd. | +86-18663721413 +86-15552573001 | rosy@litengpharm.com | China | 3280 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 2-Hydrazinopyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-01 | PYRAZIN-2-YL-HYDRAZINE
54608-52-5
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- PYRAZIN-2-YL-HYDRAZINE
54608-52-5
- $7.00
- 99%
- Career Henan Chemical Co
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