2F-LIGRL-AMIDE
- CAS No.
- Chemical Name:
- 2F-LIGRL-AMIDE
- Synonyms
- 2F-LIGRL-AMIDE;PAR-2 AGONIST I;PROTEINASE ACTIVATED RECEPTOR-2 AGONIST I
- CBNumber:
- CB9790078
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD09037554
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| PAR-2 Agonist I The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications. | 539109 | 1 mg | $184 |
| PAR-2 Agonist I The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications. | 539109 | 5 mg | $370 |
2F-LIGRL-AMIDE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 539109 | PAR-2 Agonist I The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications. | 1 mg | $184 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 539109 | PAR-2 Agonist I The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications. | 5 mg | $370 | 2026-04-30 | Buy |
2F-LIGRL-AMIDE Chemical Properties,Uses,Production
Uses
Native proteinase activated receptor-2- (PAR-2) specific agonist, SLIGRL-NH2, modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca2+]i mobilization in PAR-2-expressing cells (EC50 = 253 nM in HCT-15 cells) in vitro. Also induces PAR-2-mediated salivation (ED50 = 30 nmol/kg, i.v.) in vivo. Exhibits no effects on PAR-2-/- mice. Reactive towards human, rat, and mouse PAR-2.
The native PAR-2-specific agonist, SLIGRL-NH2, is modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca2+]i mobilization in PAR-2-expressing cells (EC50 = 253 nM using HCT-15 cells) in vitro and induce PAR-2 mediated salivation (ED50 = 30 nmol/kg, i.v.) in vivo, while exhibiting no effect on PAR-2-/- mice. Reactive towards human, rat, and murine PAR-2.
Biological Activity
Cell permeable: no', 'EC50 = 253 nM as PAR-2-specific agonist using HCT-15 cells', 'Primary Target
PAR-2', 'Product does not compete with ATP.', 'Reversible: no
2F-LIGRL-AMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2F-LIGRL-AMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Supplier | Advantage |
|---|---|
| Merck KGaA | 58 |
