ANTI-SIR2 (AS-16) RABBIT 化學(xué)特性,用途語(yǔ),生産方法
使用
Anti-Sir2 (AS-16) antibody produced in rabbit has been used in
- western blotting
- immunoprecipitation
- antibody microarray
一般的な説明
Sir2 belongs to a family of proteins that is found in organisms ranging from bacteria to complex eukaryotes. Members of this family contain a 250 amino acid core domain that shares about 25-60% sequence identity.
Biochem/physiol Actions
Sir2, one of the silent information regulator genes, encodes a protein that promotes a compact chromatin structure, thereby preventing or silencing gene transcription at selected loci. Silencing occurs as a series of events initiated by formation of Sir complexes (Sir2, Sir3, Sir4). Sir2 protein is an NAD-dependent histone deacetylase. Sir2 transfers acetyl groups from its protein substrates to ADP-ribose and synthesizes o-acetyl ADP-ribose. Through histone deacetylation, Sir2 may silence chromatin. It appears that Sir2 NAD requirement makes this protein an important player in the pathway that leads to increased life span of several species through calorie restriction.
ANTI-SIR2 (AS-16) RABBIT 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品