イプラグリFロジン 価格 もっと(6)

メーカー	製品番號	製品説明	CAS番號	包裝	価格	更新時間	購入
富士フイルム和光純薬株式會社(wako)	W01COBQK-1290	Ipragliflozin	761423-87-4	5g	￥147500	2024-03-01	購入
富士フイルム和光純薬株式會社(wako)	W01MAS123428	イプラグリfロジン Ipragliflozin	761423-87-4	1g	￥3825400	2024-03-01	購入
富士フイルム和光純薬株式會社(wako)	W01COBQK-1290	Ipragliflozin	761423-87-4	10g	￥247500	2024-03-01	購入
富士フイルム和光純薬株式會社(wako)	W01COBQK-1290	イプラグリfロジン Ipragliflozin	761423-87-4	1g	￥37500	2024-03-01	購入
富士フイルム和光純薬株式會社(wako)	W01COBQK-1290	イプラグリfロジン Ipragliflozin	761423-87-4	100mg	￥52200	2021-03-23	購入

イプラグリFロジン 化學(xué)特性,用途語,生産方法

効能

糖尿病治療薬, SGLT-2阻害薬

商品名

スーグラ (アステラス製薬)

來歴

Ipragliflozin L-proline was approved in Japan in January 2014 for the treatment of type 2 diabetes. The drug was discovered by Astellas Pharma and co-developed and marketed with Kotobuki Pharmaceutical and Merck Sharp Dohme as Suglat. Similar to empagliflozin (XIII), ipragliflozin L-proline is a sodium-glucose 1956 A. C. Flick et al. / Bioorg. Med. Chem. 24 (2016) 1937–1980 co-transporter-2 inhibitor which prevents glucose reabsorption by excreting excess glucose in the urine. Ipragliflozin exhibits remarkable selectivity over SLGT-1 (>250x).

使用

Ipragliflozin is a potent and selective inhibitor of sodium-glucose cotransporter-2 (SGLT2) and can serve as a potential agent for the treatment of type 1 and type 2 diabetes.

合成

Commercial 5-bromo-2-fluorobenzaldehyde (123) was subjected to nucleophilic attack upon subjection to lithiated benzo[b]thiophene (124) to afford the dibenzylic alcohol 125 in 85% yield. This alcohol was then halogenated by means of thionyl chloride in acetonitrile to give 126, which was followed by treatment with sodium borohydride to give rise to 2-(5-bromo-2-fluorophenyl)- 1-benzothiophene (127), which was isolated by crystallization from 2-propanol and methanol in 81% yield across the two steps. Bromide 127 then underwent lithium¨Chalogen exchange prior to exposure to 2,3,4,6-tetrakis-O-(trimethylsilyl)- D-glucono-1,5-lactone (128) in toluene. Without workup, the resulting mixture was treated with a solution of methanol and HCl at 0 C to give a globally desilylated a-glucopyranoside intermediate. Subjection to acetic anhydride and 4-dimethylaminopyridine furnished tetra-O-acetyl ipragliflozin (129) in 75% yield for the 3 steps. Polyacetate 129 was then saponified using aqueous sodium hydroxide and the product was crystallized from methanol and water and subsequently treated with D-proline in ethanol to furnish the desired product ipragliflozin D-proline (XVI) in 68% yield.

Mode of action

Ipragliflozin is a selective SGLT2 (sodium-glucose co-transporter 2) inhibitor discovered through research collaboration with Kotobuki Pharmaceutical Co., Ltd. SGLTs are membrane proteins that exist on the cell surface and transfer glucose into cells. SGLT2 is a subtype of the sodium-glucose co-transporters and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys. Ipragliflozin reduces blood glucose levels by inhibiting the reuptake of glucose.

イプラグリFロジン 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

イプラグリFロジン 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
Cangzhou Kangrui Pharma Tech Co. Ltd.,	+86-18632776803 +86-13833998158	cangzhoukangrui@126.com	China	773	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2430	58

761423-87-4(イプラグリFロジン)キーワード:

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• 761423-87-4
• Ipragliflozin, >=98%
• IpragliflozinL-Proline
• Ipragliflozin (ASP1941)
• Ipragliflozin impuity
• (1S)-1,5-Anhydro-1-C-[3-[(1-benzothiophen-2-yl)methyl]-4-fluorophenyl]-D-glucitol
• Ipragliflozin
• ASP-1941/D-Glucitol, 1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-, (1S)-
• Ipragliflozin, (1S)-1,5-Anhydro-1-C-[3-[(1-benzothiophen-2-yl)Methyl]-4-fluorophenyl]-D-glucitol
• (2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
• Ipragliflozin （Suglat）
• IpragliflozinL-Proline int
• Ipragliflozin-002
• Ipragliflozin Impurity
• CS-1580
• D-Glucitol, 1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-, (1S)-
• Suglat
• Iprag iflozin
• Igliazine
• Ipragliflozin, 10 mM in DMSO
• Iglienet free base
• Yigelejing
• Ipraglifozin
• イプラグリFロジン
• イプラグリフロジン
• イプラグリフロジンL-プロリン
• イプラグリフロジンL-プロリン (JAN)
• (2S,3R,4R,5S,6R)-2-{3-[(1-ベンゾチオフェン-2-イル)メチル]-4-フルオロフェニル}-6-(ヒドロキシメチル)オキサン-3,4,5-トリオール
• (1S)-1-[3-(1-ベンゾチオフェン-2-イルメチル)-4-フルオロフェニル]-1-デオキシ-D-グルコピラノース
• 1-フルオロ-2-(ベンゾ[b]チオフェン-2-イルメチル)-4-β-D-グルコピラノシルベンゼン
• (1S)-1,5-アンヒドロ-1-C-[3-(ベンゾ[b]チオフェン-2-イルメチル)-4-フルオロフェニル]-D-グルシトール