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CP94253塩酸塩

CP94253塩酸塩 化學構造式
845861-39-4
CAS番號.
845861-39-4
化學名:
CP94253塩酸塩
別名:
CP94253塩酸塩
英語名:
CP 94253 hydrochloride
英語別名:
CP94253 hydrochloride, 10 mM in DMSO;CP 94253 dihydrochloride, 5-HT1B agonist;1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride;CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
CBNumber:
CB03146275
化學式:
C15H20ClN3O
分子量:
293.8
MOL File:
845861-39-4.mol

CP94253塩酸塩 物理性質(zhì)

貯蔵溫度 :
Desiccate at RT
溶解性:
Soluble to 25 mM in water and to 100 mM in DMSO
外見 :
Powder
色:
Pale yellow
InChI:
InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H
InChIKey:
PIIOXKQIZCVXMD-UHFFFAOYSA-N
SMILES:
O(C1=CC=C2NC=C(C3=CCNCC3)C2=N1)CCC.Cl

安全性情報

CP94253塩酸塩 価格 もっと(2)

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
富士フイルム和光純薬株式會社(wako) W01TOC1317 CP94253塩酸塩
CP 94253 hydrochloride
845861-39-4 10mg ¥73000 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01TOC1317 CP94253塩酸塩
CP 94253 hydrochloride
845861-39-4 50mg ¥289000 2024-03-01 購入

CP94253塩酸塩 化學特性,用途語,生産方法

説明

CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.

使用

CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.

CP94253塩酸塩 上流と下流の製品情報

原材料

準備製品


CP94253塩酸塩 生産企業(yè)

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CP94253塩酸塩  スペクトルデータ(1HNMR)



  • 845861-39-4
  • 1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride
  • CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
  • CP 94253 dihydrochloride, 5-HT1B agonist
  • CP94253 hydrochloride, 10 mM in DMSO
  • CP94253塩酸塩
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