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Postion:Product Catalog >Biochemical Engineering>Amino Acids and Derivatives>Glutamic acid derivatives>Fmoc-Glu(OtBu)-OH
Fmoc-Glu(OtBu)-OH
  • Fmoc-Glu(OtBu)-OH
  • Fmoc-Glu(OtBu)-OH
  • Fmoc-Glu(OtBu)-OH
  • Fmoc-Glu(OtBu)-OH
  • Fmoc-Glu(OtBu)-OH

Fmoc-Glu(OtBu)-OH NEW

Price Get Latest Price
Package 25kg 100kg
Min. Order: 1kg
Supply Ability: 1000kg
Update Time: 2026-06-05

Product Details

Product Name: Fmoc-Glu(OtBu)-OH CAS No.: 71989-18-9
EC-No.: 276-253-8 Min. Order: 1kg
Purity: 98%min Supply Ability: 1000kg
Release date: 2026/06/05
Type: SZ01

Fmoc-Glu(OtBu)-OH Cas 71989-18-9


Specification


Items

Specifications

Results

Appearance

White powder

White powder

Solubility

0.5mmole   in 1ml DMF clearly soluble

Clearly soluble

IR   Spectrum

In   accordance with structure

In accordance with structure

Specific   Rotation[α]D20

-8.5±2.0°(C=1,MeOH)

-9.1°(C=1,MeOH)

Optical   Purity(HPLC)

≤0.10% D-enantiomer

Not detected

Water(K.F)

≤1.0%

0.6%

Fmoc-β-Ala-OH(HPLC)

≤0.10%

0.005%

Fmoc-Glu-OH(HPLC)

≤0.10%

0.002%

Fmoc-Glu(OtBu)-Glu(OtBu)-OH(HPLC)

≤0.10%

Not detected

Fmoc-β-Ala-Glu(OtBu)-OH(HPLC)

≤0.10%

Not detected

Free Glu TLC Analysis

≤0.05%

0.05%

Free   Glu(OtBu) TLC Analysis

≤0.05%

0.05%

Any   other impurity

≤0.30%

0.03%

Purity(HPLC)

≥99.0%(Area%)

99.91%

Assay(AT)

≥98.0%(AT)

98.8%

Acetic   acid ions(IC)

≤100mg/kg

53.21mg/kg

Residual   solvent(GC)

≤0.50%   Ethyl acetate

≤0.50% petroleum   ether

0.014%

0.26%

Conclusion

The product up to standard.

Welcome to contact with us to get more information.

Fmoc-L-glutamic acid 5-tert-butyl ester is a chemically modified, protected form of the amino acid L-glutamic acid. It is not found in nature but is an essential building block in modern laboratory techniques, specifically Fmoc-based solid-phase peptide synthesis (SPPS). Its primary purpose is to allow for the controlled and sequential construction of peptides (short chains of amino acids) by solving the problem of unwanted side reactions.

To understand its function, we must examine its two protecting groups:

  1. The Fmoc Group (Fluorenylmethyloxycarbonyl): This group is attached to the alpha-amino group (the main backbone nitrogen) of the glutamic acid. Its role is temporary and strategic. During the step-by-step synthesis of a peptide chain, the Fmoc group can be cleanly removed using a mild base, typically piperidine. This deprotection reveals the reactive amino group, allowing the next amino acid in the sequence to be attached. The Fmoc group is ideal because its removal is rapid and does not affect the other protecting groups on the molecule.

  2. The tert-Butyl Ester (OtBu / tBu): This group is attached specifically to the side-chain carboxylic acid of glutamic acid (the gamma-carboxyl group). Glutamic acid has two carboxylic acids: one on its main backbone (the alpha-carboxyl) and one on its side chain. The alpha-carboxyl is used to form the peptide bond, but if the side-chain carboxyl were left unprotected, it would also react, leading to branched chains, cyclization, and an incorrect final product. The tert-butyl ester protects this side chain throughout the entire synthesis process. It is stable to the basic conditions used to remove the Fmoc group but can be cleaved at the very end using a strong acid like trifluoroacetic acid (TFA).

This combination of protecting groups exemplifies an "orthogonal protection strategy," where two different types of protecting groups (one base-labile, one acid-labile) can be removed independently without affecting the other.

In practical terms, this derivative is a white, crystalline powder that is weighed out and activated to be added to a growing peptide chain anchored on a solid resin bead. Its use is critical for incorporating glutamic acid into a peptide while ensuring its side chain remains inert, preserving its intended chemical identity. After the full peptide sequence is assembled, the entire structure is treated with a strong acid, which simultaneously cleaves the finished peptide from the solid support and removes all the tert-butyl ester protecting groups, freeing the reactive glutamic acid side chains.

In summary, Fmoc-L-glutamic acid 5-tert-butyl ester is a fundamental and indispensable tool in peptide chemistry, enabling the reliable synthesis of complex peptides for research, pharmaceuticals, and diagnostics.

FeatureDescription and Function
Chemical IdentityA protected derivative of L-glutamic acid.
Primary RoleBuilding block for Fmoc solid-phase peptide synthesis (SPPS).
Fmoc GroupProtects the alpha-amino group (backbone). Removed with a base (e.g., piperidine) during chain assembly.
5-tert-Butyl EsterProtects the side-chain carboxylic acid. Removed with a strong acid (e.g., TFA) during the final cleavage step.
Key ImportanceEnables orthogonal protection, preventing the glutamic acid side chain from causing unwanted side reactions during synthesis.


Packages

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Delivery

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Payment term

* Wire Transfer/Telegraphic Transfer

* Western Union

* MoneyGram

* L/C


Contact information

Spring Zhang

Email: export@fortunachem.com  

Skype: Fortunachem201304       

QQ:3169620873

Tel:   +86-27-59207892

Website: www.fortunachem.com 



Company Profile Introduction

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber. Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement. We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

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