K 02288 価格 もっと(10)

メーカー	製品番號	製品説明	CAS番號	包裝	価格	更新時間	購入
富士フイルム和光純薬株式會社(wako)	W01TOC4986	K 02288	1431985-92-0	10mg	￥87000	2024-03-01	購入
富士フイルム和光純薬株式會社(wako)	W01COBQM-5350	3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol	1431985-92-0	100mg	￥400000	2024-03-01	購入
東京化成工業(yè)	K0065	K 02288 >98.0%(HPLC) K 02288 >98.0%(HPLC)	1431985-92-0	10mg	￥11100	2024-03-01	購入
東京化成工業(yè)	K0065	K 02288 >98.0%(HPLC) K 02288 >98.0%(HPLC)	1431985-92-0	50mg	￥38500	2024-03-01	購入
Sigma-Aldrich Japan	SML1307	>98% (HPLC) K02288 >98% (HPLC)	1431985-92-0	5mg	￥31200	2024-03-01	購入

K 02288 化學(xué)特性,用途語,生産方法

外観

白色～ほとんど白色粉末～結(jié)晶

説明

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC₅₀ values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC₅₀ values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC₅₀ = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.

使用

K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.

一般的な説明

K02288 is a 2-aminopyridine compound.

K 02288 上流と下流の製品情報

原材料

準(zhǔn)備製品

K 02288 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32468	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29093	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11680	58
Wuhan Topule Biopharmaceutical Co., Ltd	+86-18327326525	masar@topule.com	China	8467	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9942	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58

1431985-92-0(K 02288)キーワード:

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• 1431985-92-0
• LM-3151 K02288
• K 02288
• 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
• K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
• K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
• K 02288(K 02288a)
• K 02288a
• K 02288 USP/EP/BP
• 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol
• Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
• CS-1877
• K02288;K 02288;K-02288
• K02288, 10 mM in DMSO
• K02288 (K 02288
• K 02288
• K02288
• 3-[5-(3,4,5-トリメトキシフェニル)-6-アミノ-3-ピリジニル]フェノール
• 3-[6-アミノ-5-(3,4,5-トリメトキシフェニル)ピリジン-3-イル]フェノール