SB 225002
SB 225002 物理性質(zhì)
- 沸點 :
- 401.6±45.0 °C(Predicted)
- 比重(密度) :
- 1.793±0.06 g/cm3(Predicted)
- 貯蔵溫度 :
- room temp
- 溶解性:
- DMSOに100mM、エタノールに50mMに可溶
- 外見 :
- 黃色の固體
- 酸解離定數(shù)(Pka):
- 5.29±0.10(Predicted)
- 色:
- 白からベージュ
- Sensitive :
- Moisture Sensitive
- 安定性：:
- DMSO溶液またはエタノール溶液で-20°Cで最大3か月保存できます。
- InChI:
- 1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
- InChIKey:
- MQBZVUNNWUIPMK-UHFFFAOYSA-N
- SMILES:
- Brc1c(cccc1)NC(=O)Nc2c(cc(cc2)[N+](=O)[O-])O
- CAS データベース:
- 182498-32-4
SB 225002 価格
もっと(6)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TOC2725 |
SB 225002 |
182498-32-4 |
10mg |
￥78000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TOC2725 |
SB 225002 |
182498-32-4 |
50mg |
￥327000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0716 |
≥98% (HPLC)
SB225002 ≥98% (HPLC) |
182498-32-4 |
5mg |
￥23200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0716 |
≥98% (HPLC)
SB225002 ≥98% (HPLC) |
182498-32-4 |
25mg |
￥87000 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
B6055 |
>98.0%(HPLC)
SB 225002 >98.0%(HPLC) |
182498-32-4 |
10MG |
￥16400 |
2024-03-01 |
購入 |
SB 225002 化學(xué)特性,用途語,生産方法
外観
白色～黃色～緑色粉末～結(jié)晶
説明
CXCR2 (IL-
8RB) is a seven-
transmembrane G protein-
coupled receptor whose physiological ligands include IL-
8 (CXCL8) and growth related oncogene α (Gro-
α; CXCL1). IL-
8 and Gro-
α are pro-
inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-
peptide inhibitor of CXCR2, inhibiting IL-
8 binding to CXCR2 with an IC
50 value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-
8
in vitro (IC
50 = 20 nM) and blocks neutrophil margination induced by IL-
8
in vivo (IC
50 = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-
induced colitis in mice.
使用
SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.
生物活性
Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.
SB 225002 上流と下流の製品情報
原材料
準(zhǔn)備製品
SB 225002 生産企業(yè)
Global( 170)Suppliers
SB 225002 スペクトルデータ(1HNMR)
182498-32-4(SB 225002)キーワード:
- 182498-32-4
- SB 225002
- N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA
- N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA
- 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
- SB 225002 - CAS 182498-32-4 - Calbiochem
- SB-225002;SB 225002
- Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-
- SB 225002 USP/EP/BP
- SB225002 182498-32-4
- SB 225002, non-peptide CXCR2 antagonist
- SB225002, 10 mM in DMSO
- SB225002 ，S7651
- CAS:182498-32-4
- SB 225002
- 1-(2-ブロモフェニル)-3-(2-ヒドロキシ-4-ニトロフェニル)尿素
- N-(2-ブロモフェニル)-N′-(2-ヒドロキシ-4-ニトロフェニル)尿素