Mc-Val-Ala-PAB-PNP

1639939-40-4

CAS番號.: 1639939-40-4

化學名:

別名:

英語名:: Mc-Val-Ala-PAB-PNP

英語別名:: 4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate;Mc-Val-Ala-PAB-PNP;inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP;L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;[4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

CBNumber:: CB15479729

化學式:: C32H37N5O10

分子量:: 651.66

MOL File:: 1639939-40-4.mol

物理性質(zhì)

安全性情報

用途語

生産企業(yè) 63

スペクトル

Mc-Val-Ala-PAB-PNP 物理性質(zhì)

沸點 :: 946.4±65.0 °C(Predicted)

比重(密度) :: 1.323±0.06 g/cm3(Predicted)

貯蔵溫度 :: -20°C, protect from light, stored under nitrogen

外見 :: Solid

酸解離定數(shù)(Pka):: 13.31±0.70(Predicted)

色:: White to off-white

InChIKey:: VMOQJVBAOUFRSX-LGGPFLRQSA-N

SMILES:: C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1

安全性情報

Mc-Val-Ala-PAB-PNP 価格

メーカー	製品番號	製品説明	CAS番號	包裝	価格	更新時間	購入

Mc-Val-Ala-PAB-PNP 化學特性,用途語,生産方法

使用

Mc-Val-Ala-PAB-PNP is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). Cryptophycin-55 (CR55) can be conjugated to the model antibody trastuzumab (an anti-HER2 antibody drug approved by the FDA for the treatment of breast cancer) through the linker of Mc-NHS and Mc-Val-Cit-PAB-PNP to prepare trastuzumab-CR55 conjugates. These conjugates exhibit potent cytotoxicity in HER2-positive tumor cell lines, with IC50 values at low nanomolar levels (0.58-1.19 nM)^[1].

Mc-Val-Ala-PAB-PNP 上流と下流の製品情報

原材料

準備製品

Mc-Val-Ala-PAB-PNP 生産企業(yè)

Global( 63)Suppliers

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	788	58
Shanghai Huici Pharmaceutical Technology Co., LTD	+8618917134367	lixing@pharmahuici.com	China	133	58
Shanghai Huici Pharmaceutical Technology Co., LTD	+8618917134367	lixing@pharmahuici.com	China	133	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Chongqing jooe co., ltd	+undefined86-15223382610	info@jooe.com	China	15976	58

スペクトルデータ(¹HNMR)

Mc-Val-Ala-PAB-PNP(1639939-40-4)¹HNMR

1639939-40-4
Mc-Val-Ala-PAB-PNP
L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP
[4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate

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Mc-Val-Ala-PAB-PNP

Mc-Val-Ala-PAB-PNP 物理性質(zhì)

安全性情報

Mc-Val-Ala-PAB-PNP 価格

Mc-Val-Ala-PAB-PNP 化學特性,用途語,生産方法

使用

Mc-Val-Ala-PAB-PNP 上流と下流の製品情報

原材料

準備製品

Mc-Val-Ala-PAB-PNP 生産企業(yè)

スペクトルデータ(1HNMR)

スペクトルデータ(¹HNMR)