タンズチニブ 価格 もっと(6)

メーカー	製品番號(hào)	製品説明	CAS番號(hào)	包裝	価格	更新時(shí)間	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01LKTT0152	タンズチニブ Tandutinib	387867-13-2	1mg	￥20300	2024-03-01	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01LKTT0152	タンズチニブ Tandutinib	387867-13-2	5mg	￥60900	2024-03-01	購(gòu)入
Sigma-Aldrich Japan	SML2672	≥98% (HPLC) Tandutinib hydrochloride ≥98% (HPLC)	387867-13-2	25MG	￥7680	2024-03-01	購(gòu)入
Sigma-Aldrich Japan	SML2672	≥98% (HPLC) Tandutinib hydrochloride ≥98% (HPLC)	387867-13-2	100MG	￥15600	2024-03-01	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01TRCT006550	タンズチニブ Tandutinib	387867-13-2	25mg	￥18900	2024-03-01	購(gòu)入

タンズチニブ 化學(xué)特性,用途語,生産方法

効能

抗悪性腫瘍薬, 受容體チロシンキナーゼ阻害薬

説明

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC₅₀ = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC₅₀ = 3.4 μM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.

化學(xué)的特性

White Solid

使用

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelody

定義

ChEBI: An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 s replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.

タンズチニブ 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

タンズチニブ 生産企業(yè)

名前	電話番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
Sinoway Industrial co., ltd.	+86-0592-5800732 +86-13806035118	xie@china-sinoway.com	China	1370	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6366	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29807	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32468	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29120	58

387867-13-2(タンズチニブ)キーワード:

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• 387867-13-2
• Tandutinib
• 1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-
• 4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide
• Unii-E1io3icj9a
• Tandutinib(CT 53518)
• Tandutinib (MLN518)
• CT53518; MLN518
• Tandutinib(TINIBS)
• (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
• 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
• 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide
• CT 53518
• MLN 518
• Tandutinib for research
• N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide
• NSC726292
• (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide Tandutinib(MLN518)
• 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-Methylethoxy)phenyl]-
• N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-
• MLN518; CT53518; MLN 518; CT 53518; MLN-518; CT-53518;
• Tandutinib (CT53518, MLN518)
• CS-309
• Tandutinib（MLN518, CT53518）
• Tandutinib USP/EP/BP
• Tandutinib (MLN518, CT53518, NSC-726292)
• 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(...
• MLN518, Tandutinib
• Tandutinib CT53518 MLN518 CT-53518 MLN-518
• CID 3231
• Tandutinib, 10 mM in DMSO
• タンズチニブ
• 4-{6-メトキシ-7-[3-(ピペリジン-1-イル)プロポキシ]キナゾリン-4-イル}-N-[4-(プロパン-2-イルオキシ)フェニル]ピペラジン-1-カルボキサミド
• MLN-518
• N-(4-イソプロピルオキシフェニル)-1-[4-[6-(3-ピペリジノプロポキシ)-7-メトキシキナゾリン-4-イル]ピペラジノ]ホルムアミド
• 4-{7-メトキシ-6-[3-(ピペリジン-1-イル)プロポキシ]キナゾリン-4-イル}-N-[4-(プロパン-2-イルオキシ)フェニル]ピペラジン-1-カルボキサミド
• 4-[6-メトキシ-7-(3-ピペリジノプロポキシ)-4-キナゾリニル]-N-(4-イソプロポキシフェニル)ピペラジン-1-カルボアミド