SGC0946
SGC0946 物理性質(zhì)
- 融點 :
- 125-126o C
- 沸點 :
- 771.5±60.0 °C(Predicted)
- 比重(密度) :
- 1.48±0.1 g/cm3(Predicted)
- 貯蔵溫度 :
- -20°C
- 溶解性:
- DMSO：可溶20mg/mL、透明
- 酸解離定數(shù)(Pka):
- 12.39±0.70(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
- InChIKey:
- IQCKJUKAQJINMK-AZXARCNZNA-N
- SMILES:
- N(CCCN(C[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=C(Br)C3=C(N)N=CN=C32)O1)C(C)C)C(NC1=CC=C(C(C)(C)C)C=C1)=O |&1:6,7,9,11,r|
安全性情報
- リスクと安全性に関する聲明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
T |
|
|
| Rフレーズ |
25 |
|
|
| Sフレーズ |
45 |
|
|
| RIDADR |
UN 2811 6.1 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| HSコード |
2934999090 |
|
|
| ストレージクラス |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
|
|
| Hazard Classifications |
Acute Tox. 3 Oral |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
區(qū)分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
| P301+P310 |
飲み込んだ場合：直ちに醫(yī)師に連絡(luò)すること。 |
|
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
SML1107 |
≥98% (HPLC)
SGC0946 ≥98% (HPLC) |
1561178-17-3 |
5mg |
￥19900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1107 |
≥98% (HPLC)
SGC0946 ≥98% (HPLC) |
1561178-17-3 |
25mg |
￥64100 |
2024-03-01 |
購入 |
SGC0946 化學(xué)特性,用途語,生産方法
使用
SGC0946 is a potent DOT1L methyltransferase inhbiitor used in the treatment of leukemia seen effectively in vitro.
Biochem/physiol Actions
SGC0946 is a potent and selective inhibitor of Histone H3-lysine79 (H3K79) methyltransferase DOT1L with an IC50 of 0.3 nM in a radioactive enzyme assay, and over 100-fold selectivity for DOT1L over other histone methyltransferases. In cell studies, SGC0946 reduces H3K79 dimethylation with an IC50 of 2.6 nM in A431 cells and 8.8 nM in MCF10A cells. SGC0946 was found to selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia. For full characterization details, please visit the SGC0946 probe summary on the Structural Genomics Consortium (SGC) website.SGC0649 is the negative control for the active probe, SGC0946. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
SGC0946 上流と下流の製品情報
原材料
準備製品
SGC0946 生産企業(yè)
Global( 140)Suppliers
1561178-17-3()キーワード:
- 1561178-17-3
- 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahy
- SGC0946
- 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
- 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-Pyrrolo[2,3-
- 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5--bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro-xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro-pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
- 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
- SGC0946 USP/EP/BP
- sg946
- CS-1475
- CS-1937
- 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylEthyl)phenyl]amino]carbonyl]amino]propyl](1-methylEthyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- SGC0946, 10 mM in DMSO
- MCE SGC0946
- SGC 0946 ，S7079