デメチルクロルテトラサイクリン塩酸塩 化學特性,用途語,生産方法
外観
黃色～緑黃色, 結(jié)晶性粉末～粉末
溶解性
水及びエタノールに溶け、アセトンにほとんど溶けない。
効能
抗生物質(zhì), タンパク質(zhì)合成阻害薬
商品名
レダマイシン (ポーラファルマ)
使用上の注意
アルゴン封入
説明
Demeclocycline lacks the C-6-methyl of tetracycline and is produced by a genetically altered strain of
Streptomyces aureofaciens. Because it is a secondary alcohol, it is more chemically stable than tetracycline
against dehydration. Food and milk co-consumption decrease absorption by half, although it is 60 to 80%
absorbed by fasting adults. It is the tetracycline most highly associated with phototoxicity and has been
shown to produce dose-dependent, reversible diabetes insipidus with extended use.
化學的特性
Yellow Solid
使用
Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.
定義
ChEBI: The hydrochloride salt of demeclocycline. A tetracycline antibiotic, it is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inapp
opriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.
抗菌性
Occasional strains of viridans streptococci,
N. gonorrhoeae and H. influenzae are more susceptible than to tetracycline.
It is the most active tetracycline against Brucella spp.
一般的な説明
Demeclocycline, 7-chloro-6-demethyltetracycline (Declomycin),was isolated in 1957 by McCormick et al. from amutant strain of S. aureofaciens. Chemically, it is 7-chloro-4-(dimethylamino)1,4,4a,5,5a,6, 11, 12a-octahydro-3, 6, 10, 12,12a-pentahydroxy1, 11-dioxo2-naphthacenecarboxamide.Thus, it differs from chlortetracycline only in the absence ofthe methyl group on C-6.
Demeclocycline is a yellow, crystalline powder that isodorless and bitter. It is sparingly soluble in water. A 1% solutionhas a pH of about 4.8. It has an antibiotic spectrumlike that of other tetracyclines, but it is slightly more activethan the others against most of the microorganisms forwhich they are used. This, together with its slower rate ofelimination through the kidneys, makes demeclocycline aseffective as the other tetracyclines, at about three fifths ofthe dose. Like the other tetracyclines, it may cause infrequentphotosensitivity reactions that produce erythema afterexposure to sunlight. Demeclocycline may produce this reactionsomewhat more frequently than the other tetracyclines.The incidence of discoloration and mottling of theteeth in youths from demeclocycline appears to be as low asthat from other tetracyclines.
応用例（製薬）
6-Demethyl-7-chlortetracycline. A fermentation product of a
mutant strain of Streptomyces aureofaciens formulated as the
hydrochloride for oral administration.
薬物動態(tài)學
Oral absorption： 60–70%
C
max 300 mg oral：2 mg/L after 3–6 h
Plasma half-life：c.12 h
Volume of distribution：c.1.7 L/kg
Plasma protein binding：90%
Absorption
It is promptly yet incompletely absorbed by mouth, giving
mean peak plasma levels after a single dose that are slightly
higher than those produced by oxytetracycline and chlortetracycline,
but lower than those achieved by tetracycline.
However, with repeat dosing, steady-state concentrations
exceed those for tetracycline. Simultaneous administration of
antacids markedly depresses blood levels.
Distribution and excretion
It is widely distributed, achieving concentrations in pleural
exudates
similar to those of blood. CSF penetration is
poor, especially in the absence of inflammation. Biliary
concentrations
are 20–30 times higher than those of plasma, and 40–50% of the drug can be recovered from feces. The
other route of elimination is via glomerular filtration without
reabsorption and accumulation occurs in renal failure.
臨床応用
It has been extensively used in the management of the syndrome
of inappropriate ADH secretion in a dose of at least
1.2 g per day; therapeutic response may take several days, but
is superior to that of lithium. It has also found occasional use
in patients with water retention as a result of congestive cardiac
failure and in those with alcoholic cirrhosis and water
and electrolyte retention.
副作用
Untoward reactions, notably gastrointestinal intolerance,
are generally those typical of the group. Occasional
patients develop transient steatorrhea.
Of particular note is the occurrence of nephrogenic diabetes
insipidus with development of vasopressin-resistant polyuria.
The effect is dose dependent and occurs with daily doses
in excess of 1.2 g. The drug inhibits activation of adenylate
cyclase and protein kinase, which are both important in the
interaction of antidiuretic hormone (ADH) with receptors
within the renal tubule, thus decreasing the effect of ADH on
the kidney. As a result, it has found a place in the treatment of
inappropriate ADH secretion.
Renal failure may occur, particularly if prescribed for those
with advanced liver cirrhosis. The mechanism is uncertain but
may in part be related to the antianabolic effect of the tetracyclines
as well as a direct toxic effect.
Photosensitivity may be severe and accompanied by vesiculation,
edema and onycholysis. It is largely restricted to exposed
skin; patients should avoid prolonged exposure to sunlight.
純化方法
Crystallise the salt from EtOH/Et2O or H2O and dry it in air [McCormick et al. J Am Chem Soc 79 4561 1957, Dobrynin et al. Tetrahedron Lett 901 1962]. [Beilstein 14 IV 2625.]
デメチルクロルテトラサイクリン塩酸塩 上流と下流の製品情報
原材料
準備製品