5-フルオロオキシインドール
5-フルオロオキシインドール 物理性質(zhì)
- 融點(diǎn) :
- 143-147 °C (lit.)
- 沸點(diǎn) :
- 307.2±42.0 °C(Predicted)
- 比重(密度) :
- 1.311±0.06 g/cm3(Predicted)
- 貯蔵溫度 :
- Sealed in dry,Room Temperature
- 溶解性:
- クロロホルム（微量）、メタノール（微量）
- 外見 :
- 粉末または結(jié)晶性粉末
- 酸解離定數(shù)(Pka):
- 12.99±0.20(Predicted)
- 色:
- 白色～薄茶色
- InChI:
- InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
- InChIKey:
- DDIIYGHHUMKDGI-UHFFFAOYSA-N
- SMILES:
- N1C2=C(C=C(F)C=C2)CC1=O
- CAS データベース:
- 56341-41-4(CAS DataBase Reference)
5-フルオロオキシインドール 価格
もっと(26)
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBIN-0072 |
5-フルオロオキシンドール
5-Fluorooxindole |
56341-41-4 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBIN-0072 |
5-フルオロオキシンドール
5-Fluorooxindole |
56341-41-4 |
100g |
￥42500 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
F0699 |
5-フルオロオキシインドール >98.0%(GC)
5-Fluorooxindole
>98.0%(GC) |
56341-41-4 |
1g |
￥5100 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
F0699 |
5-フルオロオキシインドール >98.0%(GC)
5-Fluorooxindole
>98.0%(GC) |
56341-41-4 |
5g |
￥16400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
586579 |
97%
5-Fluoro-2-oxindole 97% |
56341-41-4 |
500mg |
￥11700 |
2023-06-01 |
購入 |
5-フルオロオキシインドール 化學(xué)特性,用途語,生産方法
外観
白色～うすい褐色、結(jié)晶性粉末～粉末
使用上の注意
アルゴン封入
化學(xué)的特性
Light Yellow Crystalline
使用
5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.
主な応用
5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.
製造方法
synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.
生物活性
5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain.
5-フルオロオキシインドール 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
5-フルオロオキシインドール 生産企業(yè)
Global( 635)Suppliers
5-フルオロオキシインドール スペクトルデータ(1HNMR)
56341-41-4(5-フルオロオキシインドール)キーワード:
- 56341-41-4
- 5-Fluorooxindole 98%
- 5-FLUROOXINDOLE
- 5-FLUORO-2-OXINDOLE, 98+%
- 5-Fluoro-2-indolinone
- 5-Fluoro-2-oxindole 98%
- 1,3-Dihydro-5-fluoro-2H-indol-2-one, 5-Fluoroindolin-2-one
- 5-Fluoro-2,3-dihydro-2-oxoindole
- 5-FLUORO-2-OXINDOLE (RETURNED FOR RE-EXP
- 5-Fluoroindole-2-One
- 5-FLUORO-2-OXINDOLE
- 5-Fluorooxindole98%
- 2H-Indol-2-one,5-fluoro-1,3-dihydro-(9CI)
- 5-FLUORO-2-NITROPHENYLACETATE
- 2H-Indol-2-one, 5-fluoro-1,3-dihydro-
- Fluorooxindole
- 1H-indol-5-yl hypofluorite
- 5-Fluoro-2-oxindole 5-Fluorooxindole
- 5‐fluoro‐2,3‐dihydro‐1H‐indol‐2‐one
- Sunitinib Impurity 49
- 5-Fluoro-2-oxindole in stock Factory
- 5-Fluorooxindole>
- 5-Fluor0-2-oxindole
- 5-Flouro-1,3-dihydro-indole-2-one
- Sunitinib Impurity 26
- 5-Fluorooxindole (5-Fluoro-1,3-dihy
- uorooxindoL
- 5-Fluoro-2-oxindole ISO 9001：2015 REACH
- 5-Fluorooxindole (5-Fluoro-1,3-dihydro-2H-indol-2-one)
- 5-Fluoro-2-oxoindoline
- 5-flouro-1,3-dihydroindol-2-one,5-flouro-2,3-dihydro-2-oxoindole
- 5-フルオロオキシインドール
- 5-フルオロ-2-インドリノン
- 5-フルオロ-2-オキシインドール
- 5-フルオロオキシンドール
- 5-フルオロ-2,3-ジヒドロ-1H-インドール-2-オン