N-シアノ-N'-(1,1-ジメチルプロピル)-N''-(3-ピリジル)グアニジン 価格

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N-シアノ-N'-(1,1-ジメチルプロピル)-N''-(3-ピリジル)グアニジン 化學(xué)特性,用途語,生産方法

使用

N-Cyano-N''-(1,1-dimethylpropyl)-N''''-3-pyridinyl-guanidine is an ATP-sensitive potassium channels activator or opener (KATPCO) by causing relaxation of various isolated animal and human blood vessels.

生物活性

Potent K ATP channel opener (EC 50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (K d values are 17 and 3 nM respectively).

酵素阻害剤

This potent potassium ion channel opener, or KCO (FW = 231.30 g/mol; CAS 60559-98-0; Solubility: 50 mM in Ethanol; 100 mM in DMSO), also known as N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridyl-guanidine, targets Kir6 (or KATP) channels (EC50 = 7.5 nM; for relaxation of rat aorta). In studies on rats, rabbit and dogs, P1075 effects only correlate with the presence of specific receptor binding sites in rat vascular preparations, showing there are significant species-specific and raising questions about the pharmacological significance of this KATP opener binding site. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K+ channel subunit plus a regulatory subunit comprising the receptor sites for hypoglycemic sulfonylureas and KCOs (a sulfonylurea receptor). P1075-induced channel activation IS mediated by drug interaction with a single binding site per tetradimeric complex. P-1075 also binds to sulfonylurea receptors SUR2A (Kd = 17 nM) and SUR2B (Kd = 3 nM)

N-シアノ-N'-(1,1-ジメチルプロピル)-N''-(3-ピリジル)グアニジン 上流と下流の製品情報

原材料

準(zhǔn)備製品

N-シアノ-N'-(1,1-ジメチルプロピル)-N''-(3-ピリジル)グアニジン 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Aladdin Scientific		tp@aladdinsci.com	United States	57473	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15815	69
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai Raise Chemical Technology Co.,Ltd	15026594951	rs@raise-chem.com	China	4837	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	13636370518	shyysw007@163.com	China	89667	60
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9718	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58

60559-98-0(N-シアノ-N'-(1,1-ジメチルプロピル)-N''-(3-ピリジル)グアニジン)キーワード:

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• 60559-98-0
• P1075
• N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE
• 2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidin
• 2-cyano-1-tert-pentyl-3-(3-pyridyl)guanidine
• n-cyano-n’-(1,1-dimethylpropyl)-n’’-3-pyridinyl-guanidin
• N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine
• Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-
• -(1,1-dimethylpropyl)-N&rsquo
• -3-pyridinyl-guanidine
• Inhibitor,Potassium Channel,P1075,KcsA,COS-7,adult rabbit cardiomyocytes,inhibit,P 1075,P-1075
• P-1075, 10 mM in DMSO
• 2-シアノ-1-tert-ペンチル-3-(3-ピリジル)グアニジン
• 1-(3-ピリジニル)-2-シアノ-3-(1,1-ジメチルプロピル)グアニジン
• N-シアノ-N'-(1,1-ジメチルプロピル)-N''-(3-ピリジニル)グアニジン
• N-シアノ-N'-(1,1-ジメチルプロピル)-N''-(3-ピリジル)グアニジン
• N'-シアノ-N-(2-メチルブタン-2-イル)-N''-(ピリジン-3-イル)グアニジン
• P-1075
• N-シアノ-N′-(1,1-ジメチルプロピル)-N′′-(3-ピリジニル)グアニジン
• N-シアノ-N′-(1,1-ジメチルプロピル)-N′′-(3-ピリジル)グアニジン