603101-22-0
603101-22-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.44±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)8.68±0.70(Predicted)
形態(tài)Solid
顏色Yellow to brown
應(yīng)用領(lǐng)域
用途一
GNF-1331 is a Potent, Selective, and Orally Bioavailable Porcupine Inhibitor (IC50 = 12 nM). Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.