ベニジピン塩酸塩
ベニジピン塩酸塩 物理性質(zhì)
- 融點 :
- 199-201°C
- 貯蔵溫度 :
- Inert atmosphere,Store in freezer, under -20°C
- 溶解性:
- DMSO：20mg/mL以上
- 酸解離定數(shù)(Pka):
- 7.34(at 25℃)
- 外見 :
- 粉
- 色:
- 黃色
- InChIKey:
- DGVVISBYHUXFIU-UHFFFAOYSA-N
- SMILES:
- C(C1=C(NC(=C([C@H]1C1C=CC=C(C=1)N(=O)=O)C(=O)OC)C)C)(=O)O[C@@H]1CCCN(C1)CC1C=CC=CC=1.Cl
- CAS データベース:
- 91599-74-5(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する聲明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
T |
|
|
| Rフレーズ |
25 |
|
|
| Sフレーズ |
45 |
|
|
| RIDADR |
UN 2811 6.1 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| RTECS 番號 |
US7975657 |
|
|
| HSコード |
2933.99.5300 |
|
|
| 國連危険物分類 |
6.1 |
|
|
| ストレージクラス |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
|
|
| Hazard Classifications |
Acute Tox. 3 Oral |
|
|
| 毒性 |
LD50 orally in male mice: 218 mg/kg (Muto, 1988) |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
區(qū)分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
| P301+P310 |
飲み込んだ場合：直ちに醫(yī)師に連絡(luò)すること。 |
|
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCB157500 |
ベニジピン塩酸塩
rac Benidipine Hydrochloride |
91599-74-5 |
100mg |
￥35100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCB157500 |
ベニジピン塩酸塩
rac Benidipine Hydrochloride |
91599-74-5 |
1g |
￥267900 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
B5629 |
ベニジピン塩酸塩 >98.0%(HPLC)(T)
Benidipine Hydrochloride
>98.0%(HPLC)(T) |
91599-74-5 |
100mg |
￥13400 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
B5629 |
ベニジピン塩酸塩 >98.0%(HPLC)(T)
Benidipine Hydrochloride
>98.0%(HPLC)(T) |
91599-74-5 |
1g |
￥80300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
46510-1A |
Benidipine hydrochloride |
91599-74-5 |
1g |
￥100650 |
2024-07-01 |
購入 |
ベニジピン塩酸塩 化學(xué)特性,用途語,生産方法
外観
うすい黃色～褐色, 結(jié)晶～粉末
溶解性
ぎ酸に極めて溶けやすく、メタノールにやや溶けやすく、エタノール(99.5)にやや溶けにくく、水にほとんど溶けない。
効能
血圧降下薬, 血管拡張薬, カルシウムチャネル遮斷薬
商品名
コニール (協(xié)和発酵キリン)
説明
Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals,
benidipine hydrochloride dose dependently induced hypotension with a potency of
6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a
slow onset of action.
化學(xué)的特性
Yellow Crystalline Powder
使用
A dihydropyridine calcium channel blocker. Antihypertensive.
生物活性
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.
安全性プロファイル
A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.
ベニジピン塩酸塩 上流と下流の製品情報
原材料
準(zhǔn)備製品
ベニジピン塩酸塩 生産企業(yè)
Global( 345)Suppliers
91599-74-5(ベニジピン塩酸塩)キーワード:
- 91599-74-5
- (R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT
- Coniel, Capadipine, KW-3049, Nacadipine
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-
- (R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride
- Benidipine hydrochloride
- monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste
- 1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE
- 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-DimethoxyCarboxylate
- (R,R)-(+/)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidmethyl-1-(phenylmethyl)-3-piperidiny
- Benidipine hydrochlo
- (4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1)
- (4R)-rel-3,5-Pyridinedicarboxylic acid
- 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester
- Conipros
- rac-(4R*)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R*)-1-benzylpiperidine-3-yl]·hydrochloride
- (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid3-methyl5-[(3R)-1-(phenylmethyl)-3-piperidinyl]esterhydrochloride
- rac Benidipine Hydrochloride
- 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-
- rac-Benidipine HCl
- Benidipine Impurity 4
- 3-[(3RS)-1-Benzylpiperidin-3-yl] 5-Methyl (4RS)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
- Benidipine hydrochloride USP/EP/BP
- (R)-rel-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
- 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride
- (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
- 3-[(R*)-1-Benzylpiperidin-3-yl] (R*)-5-Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
- Benidipin
- (R,R)(S,S)-Benidipine Hydrochloride
- (±)-(R*)-3-[(R*)-1-Benzyl-3-piperidyl]methyl 1,4-dihydro-2,6-dimethyl- 4-(m-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride
- (±)-ベニジピン塩酸塩
- rac-(4R*)-1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸3-メチル5-[(3R*)-1-ベンジルピペリジン-3-イル]·塩酸塩
- (±)-塩酸ベニジピン
- ベニジピン塩酸塩
- 塩酸ベニジピン
- コニプロス
- コニール
- ベニトーワ
- ベニジピン 塩酸塩
- ベニジピン塩酸塩 (JP17)
- rac-(4R*)-1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)ピリジン-3,5-ジカルボン酸3-メチル5-[(3R*)-1-ベンジルピペリジン-3-イル]?塩酸塩
- カルシウム拮抗薬
- 冠拡張薬
- 降圧薬