トリメチルアミンN-オキシド (無水) 化學(xué)特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結(jié)晶
性質(zhì)
1) (サカナ，ヒト尿)，弱いクラーレ作用2) 加熱分解( → (CH3)2NH+H2CO3), ピクラート〔187～202 °C〕
定義
本品は、次の化學(xué)式で表される3級アミンオキシドである。
化粧品の成分用途
保水剤、香料
説明
Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine . It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver. Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone
ApoE-/- mice. Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis. Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.
化學(xué)的特性
White crystalline powder
使用
Trimethylamine
N-oxide can be used:
- As a demetallationand decarbonylationreagent for organometallic compounds.
- To prepare azomethine ylide by reaction with lithium di-isopropylamide. This, in turn, may be reacted with simple alkenes to obtain corresponding pyrrolidines.
- To mediate the conversion of thiols to disulfides.
定義
ChEBI: An N-oxide derived from triethylamine.
一般的な説明
Trimethylamine
N-oxide is an organic compound that belongs to the class of amine oxides. It is generally found in the tissues of marine organisms, wherein it helps protect them from harsh conditions like salinity, hydrostatic pressure, temperature, and high urea.
トリメチルアミンN-オキシド (無水) 上流と下流の製品情報
原材料
準(zhǔn)備製品