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アルテプラーゼ

アルテプラーゼ 化學(xué)構(gòu)造式
105857-23-6
CAS番號.
105857-23-6
化學(xué)名:
アルテプラーゼ
別名:
アルテプラーゼ;アルテプラーゼ(遺伝子組換え)
英語名:
Alteplase
英語別名:
D02837;Alteplase;Activase (tn);Alteplase (usp/inn);Alteplase USP/EP/BP;Sparsentan Impurity 44;ALTEPLASE(105857-23-6);Alteplase (genetical recombination);Alteplase (genetical recombination) (jan);PlasMinogen activator (huMan tissue-type protein Moiety) (9CI)
CBNumber:
CB61401954
化學(xué)式:
分子量:
0
MOL File:
Mol file

アルテプラーゼ 物理性質(zhì)

外見 :
Solid
色:
White to off-white

安全性情報

アルテプラーゼ 価格

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入

アルテプラーゼ 化學(xué)特性,用途語,生産方法

用途

血栓溶解薬血栓の主要成分であるフィブリンを分解する

説明

Alteplase is a recombinant single-chain tissue plasminogen activator useful in the management of thrombosis in acute myocardial infarct. It reportedly causes no allergic reactions but requires intravenous infusion due to a short half-life. Alteplase is the only agent on the U.S. market indicated for the reduction of incidence of congestive heart failure following a heart attack.

使用

Tissue-type plasminogen activator; fibrinolytic.

一般的な説明

Alteplase (Activase) is a tissue plasminogenactivator (t-PA) produced by rDNA technology. It is a single-chain glycoprotein protease consisting of 527 aminoacid residues. Native t-PA is isolated from a melanoma cellline. The single-chain molecule is susceptible to enzymaticdigestion to a two-chain molecule, in which the two chainsremain linked with a disulfide bond. Both forms of the nativet-PA are equipotent in fibrinolytic (and plasminogenactivating)properties. It is an extrinsic plasminogen activatorassociated with vascular endothelial tissue, whichpreferentially activates plasminogen bound to fibrin. Thefibrinolytic action of alteplase (t-PA) is confined to thrombi,with minimal systemic activation of plasminogen. It is producedcommercially by rDNA methods by inserting the alteplasegene (acquired from human melanoma cells) intoovarian cells of the Chinese hamster, serving as host cells.The melanoma-derived alteplase is immunologically andchemically identical with the uterine form. Alteplase is indicatedfor the intravenous management of acute myocardialinfarction.

作用機(jī)序

As a main endogenic promoter of fibrinolysis, t-PA binds with fibrin and, like urokinase, breaks Arg-560–Val-561 peptide bond in the fibrin-binded plasminogen molecule, thus turning it into an active plasmin molecule that breaks apart fibrin clots. Its action is localized in thrombotic regions, and thus the likelihood of systemic fibrinolysis originating during its use is much lower than that which can originate while using streptokinase and urokinase.

臨床応用

Alteplase (tPA) is a serine protease with a low affinity for free plasminogen but a very high affinity for the plasminogen bound to fibrin in a thrombus (fibrin-specific agent). Both streptokinase and urokinase lack this specificity (i.e., are nonspecific) and act on free plasminogen, inducing a generalized thrombolytic state. Alteplase also has a greater specificity for older clots compared with newer clots relative to streptokinase and urokinase. Alteplase was originally isolated from cultures of human melanoma cells but is now produced commercially using recombinant DNA technology.

副作用

Alteplase is unmodified human tPA, whereas reteplase is human tPA that has had several specific amino acid sequences removed. At low doses, alteplase is quite selective for degrading fibrin without concomitant lysis of other proteins, such as fibrinogen. At the higher doses currently used therapeutically, however, alteplase activates free plasminogen to some extent and, therefore, can cause hemorrhage. Many of the therapeutic indications for the other thrombolytic agents also are indications for alteplase (i.e., myocardial infarction, massive pulmonary embolism, and acute ischemic stroke).

アルテプラーゼ 上流と下流の製品情報

原材料

準(zhǔn)備製品


アルテプラーゼ 生産企業(yè)

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