セフォジジム
セフォジジム 物理性質(zhì)
- 融點 :
- >170°C (dec.)
- 比旋光度 :
- D25 -55.9°
- 比重(密度) :
- 1.86±0.1 g/cm3(Predicted)
- 貯蔵溫度 :
- -20°C Freezer
- 溶解性:
- DMSO（微量）、メタノール（微量、加溫）
- 外見 :
- 個體
- 酸解離定數(shù)(Pka):
- pK1 2.85; pK2 3.37; pK3 4.18(at 25℃)
- 色:
- ホワイトからオフホワイト
- InChIKey:
- XDZKBRJLTGRPSS-BGZQYGJUSA-N
- SMILES:
- N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\OC)=O)C1=O)SCC(CSC1=NC(C)=C(CC(O)=O)S1)=C2C(O)=O
- CAS データベース:
- 69739-16-8(CAS DataBase Reference)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCC242865 |
セフォジジム
Cefodizime |
69739-16-8 |
25mg |
￥20400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCC242865 |
セフォジジム
Cefodizime |
69739-16-8 |
50mg |
￥26700 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCC242865 |
セフォジジム
Cefodizime |
69739-16-8 |
100mg |
￥40500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCC242865 |
セフォジジム
Cefodizime |
69739-16-8 |
1g |
￥48000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCC242865 |
セフォジジム
Cefodizime |
69739-16-8 |
10g |
￥124600 |
2023-06-01 |
購入 |
セフォジジム 化學特性,用途語,生産方法
効能
抗生物質(zhì), 細胞壁合成阻害薬
化學的特性
Cefodizime Sodium is a white to light yellowish white crystalline powder. It has no odor or a slightly peculiar odor and has a bitter taste. It is highly soluble in water (around 270g/L) but only sparingly soluble in ethanol or ether.
製造方法
The synthesis of cefodizime involved the following steps:
Dissolve 6.1g of (2-mercapto-4-methylthiazol-5-yl) acetic acid in water and adjust the pH to 6.5 by adding 2 mol/L sodium hydroxide.
Heat the solution to 70°C and then add a solution of 12g of cefotaxime in 75ml of water with stirring.
Keep stirring the mixture at 70°C for 3 hours while maintaining the pH at 6.5 by adding 2 mol/L sodium hydroxide.
Cool the mixture to room temperature and acidify it to pH 2.8.
Filter the resulting precipitate and wash it with water.
Dry the precipitate under vacuum and in the presence of phosphorus pentoxide.
As a result, 10g of cefodizime is obtained.
Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series. DOI:
10.7164/antibiotics.40.29
定義
ChEBI: Cefodizime is a cephalosporin compound having 5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It has a role as an antibacterial drug and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a cephalosporin, a member of 1,3-thiazoles and an oxime O-ether.
セフォジジム 上流と下流の製品情報
原材料
準備製品
セフォジジム 生産企業(yè)
Global( 180)Suppliers
69739-16-8(セフォジジム)キーワード:
- 69739-16-8
- CEFODIZIME
- Cefodizime,CDZM
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-
- 7-(α-(Z)-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido)-3-((5-carboxymethyl-4-methylthiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid
- 7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
- FIR-221
- Cefodizme
- CefodizMe SodiuM
- Sodium cefodizime
- Cefodizim
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-
- CEFODIZIME FREE ACID
- CefodiziMe acid USP/EP/BP
- Cefodizime USP/EP/BP
- (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((5-(carboxymethyl)-4-methylthiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Estrofan
- (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cefodizime, 10 mM in DMSO
- セフォジジム
- (6R,6β)-7α-[[(2-アミノ-4-チアゾリル)[(Z)-メトキシイミノ]アセチル]アミノ]-3-[[[5-(カルボキシメチル)-4-メチル-2-チアゾリル]チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
- (6R,7R)-3-[[(4-メチル-5-カルボキシメチル-2-チアゾリル)チオ]メチル]-7α-[[(2Z)-メトキシイミノ(2-アミノ-4-チアゾリル)アセチル]アミノ]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
- (6R,7R)-7-[[(Z)-(2-アミノ-4-チアゾリル)(メトキシイミノ)アセチル]アミノ]-3-[[[5-(カルボキシメチル)-4-メチル-2-チアゾリル]チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
- セホタキサミン
- セホジジン
- セホジジム
- (6R,7R)-7α-[2-(2-アミノ-4-チアゾリル)-2-[(Z)-メトキシイミノ]アセチルアミノ]-3-[[[5-(カルボキシメチル)-4-メチル-2-チアゾリル]チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
- (6R,7R)-7-[(2Z)-2-(2-アミノ-1,3-チアゾール-4-イル)-2-(メトキシイミノ)アセトアミド]-3-({[5-(カルボキシメチル)-4-メチル-1,3-チアゾール-2-イル]スルファニル}メチル)-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸