5,6,7,4'-テトラヒドロキシフラボン 化學(xué)特性,用途語(yǔ),生産方法
外観
うすい黃色~くすんだ黃色~暗い緑色粉末~結(jié)晶
説明
Scutellarein is a flavone that has been isolated from
S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC
50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.
In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.
化學(xué)的特性
Yellow solid
使用
Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.
定義
ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.
5,6,7,4'-テトラヒドロキシフラボン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品