97919-22-7
97919-22-7 結構式
基本信息
Chlorsulfaquinoxaline
Chloroquinoxaline sulfonamide
5-chloroquinoxaline-2-sulfanilamide
4-Amino-N-(5-chloroquinoxalin-2-yl)benzenesulfonamide
4-amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide
Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-
物理化學性質
常見問題列表
|
topoisomerase II alpha
|
topoisomerase II beta
|
The Chloroquinoxaline sulfonamide IC
50
for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links.
Chloroquinoxaline sulfonamide (Chloroquinoxaline), a chlorinated derivative of sulfaquinoxaline, inhibits proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used.
Cell Proliferation Assay
| Cell Line: | B16 murine melanoma cells |
| Concentration: | 10 μM, 100 μM, 1 mM |
| Incubation Time: | 24, 48, 72 hours |
| Result: | Inhibited proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) were used. |