N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
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- CAS番號(hào).
- 182182-31-6
- 化學(xué)名:
- 別名:
- 英語(yǔ)名:
- N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
- 英語(yǔ)別名:
- Exatecan Impurity 2;Exatecan Intermediate;Exatecan Intermediate 2;N-(8-amino-6-fluoro-5-methyl-1-oxo-tetralin-2-yl)acetamide;N-(8-amino-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide;N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide;N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)acetamide;N-(8-amino-6-fluoro-1,2,3,4-tetrahydro-5-methyl-1-oxo-2-naphthalenyl)-acetamide;N-(8-amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalene-2-yl)acetamide;N-(8-acetamido-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide
- CBNumber:
- CB74667363
- 化學(xué)式:
- C13H15FN2O2
- 分子量:
- 250.27
- MOL File:
- 182182-31-6.mol
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N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 物理性質(zhì)
- 融點(diǎn) :
- 200-210°
- 沸點(diǎn) :
- 550.1±50.0 °C(Predicted)
- 比重(密度) :
- 1.27±0.1 g/cm3(Predicted)
- 貯蔵溫度 :
- Keep in dark place,Sealed in dry,2-8°C
- 酸解離定數(shù)(Pka):
- 14.41±0.20(Predicted)
- 外見(jiàn) :
- Solid
- 色:
- Off-white to gray
- InChI:
- InChI=1S/C13H15FN2O2/c1-6-8-3-4-11(16-7(2)17)13(18)12(8)10(15)5-9(6)14/h5,11H,3-4,15H2,1-2H3,(H,16,17)
- InChIKey:
- SEFPQWAVZCZXTK-UHFFFAOYSA-N
- SMILES:
- C(NC1CCC2=C(C1=O)C(N)=CC(F)=C2C)(=O)C
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 価格
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製品番號(hào) |
製品説明 |
CAS番號(hào) |
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N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 化學(xué)特性,用途語(yǔ),生産方法
説明
N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide is an intermediate of Exatecan. Exatecan is used as a component of antibody-drug conjugates for cancer research.
使用
N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide is an important pharmaceutical raw material that is a by-product of the ezetimibe preparation process.
合成
N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide is synthesised from N,N'-(3-fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diethanamide by reaction in the presence of inert gas. The steps are as follows:
Add compound (15.5 g) to a solution of 2N hydrochloric acid (620 mL) and methanol (620 mL), protect with argon, and react at 60°C for 0.5 hours. The temperature is reduced to 010°C, and sodium carbonate (65.7 g ) In water (1314 mL) solution to pH=34, and then neutralized to pH=67 with saturated sodium bicarbonate solution, filtered, washed with 100 mL water, and dried to obtain N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide as a solid powder (12.4 g , 93%).
N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 生産企業(yè)
Global( 124)Suppliers
182182-31-6()キーワード:
(4S)-4-エチル-7,8-ジヒドロ-4-ヒドロキシ-1H-ピラノ[3,4-F]インドリジン-3,6,10(4H)-トリオン
(4S,15S)-4α-エチル-4-ヒドロキシ-8-フルオロ-9-メチル-15-(ヒドロキシアセチルアミノ)-10,11-プロパノ-3,4,12,14-テトラヒドロ-1H-ピラノ[3′,4′:6,7]インドリジノ[1,2-b]キノリン-3,14-ジオン
- 182182-31-6
- N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
- N-(8-amino-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide
- N-(8-acetamido-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide
- Acetamide, N-(8-amino-6-fluoro-1,2,3,4-tetrahydro-5-methyl-1-oxo-2-naphthalenyl)-
- N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide hydrochloride
- N-(8-amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalene-2-yl)acetamide
- Exatecan Intermediate 2
- Exatecan Impurity 2
- N-(8-amino-6-fluoro-1,2,3,4-tetrahydro-5-methyl-1-oxo-2-naphthalenyl)-acetamide
- N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)acetamide
- N-(8-amino-6-fluoro-5-methyl-1-oxo-tetralin-2-yl)acetamide
- Exatecan Intermediate