ベシル酸シサトラクリウム
ベシル酸シサトラクリウム 物理性質
- 融點 :
- 90-93°C
- 貯蔵溫度 :
- Sealed in dry,Store in freezer, under -20°C
- 溶解性:
- H2O: ソリュブル1mg/mL
- 外見 :
- Powder
- 色:
- 白い
- 主な用途:
- 醫(yī)薬品（低分子化合物）
- InChIKey:
- XXZSQOVSEBAPGS-UHFFFAOYSA-L
安全性情報
- リスクと安全性に関する聲明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
T |
|
|
| Rフレーズ |
25-36 |
|
|
| Sフレーズ |
45 |
|
|
| RIDADR |
UN 2811 6.1 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| HSコード |
29145090 |
|
|
| ストレージクラス |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
|
|
| Hazard Classifications |
Acute Tox. 3 Oral |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
區(qū)分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P301+P310 |
飲み込んだ場合：直ちに醫(yī)師に連絡すること。 |
| P405 |
施錠して保管すること。 |
| P501 |
內容物/容器を．．．に廃棄すること。 |
|
ベシル酸シサトラクリウム 価格
もっと(10)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01LKTC3472 |
Cisatracurium Besylate
Cisatracurium Besylate |
96946-42-8 |
5mg |
￥18900 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01LKTC3472 |
ベシル酸シサトラクリウム
Cisatracurium Besylate |
96946-42-8 |
25mg |
￥29200 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01LKTC3472 |
ベシル酸シサトラクリウム
Cisatracurium Besylate |
96946-42-8 |
100mg |
￥97300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01TRCC496700 |
ベシル酸シサトラクリウム (?90%)
Cisatracurium Besylate (?90%) |
96946-42-8 |
25mg |
￥56900 |
2023-06-01 |
購入 |
|
Sigma-Aldrich Japan
|
Y0001766 |
EuropePharmacopoeia (EP) Reference Standard
Cisatracurium besilate EuropePharmacopoeia (EP) Reference Standard |
96946-42-8 |
y0001766 |
￥24800 |
2024-03-01 |
購入 |
ベシル酸シサトラクリウム 化學特性,用途語,生産方法
効能
神経筋遮斷薬
説明
Cisatracurium besylate is a new intermediate-duration non-depolarizing muscle
relaxant launched in the U.S.A. for intubation and maintenance of muscle
relaxation during surgery and intensive care. Cisatracurium besylate is the single 1 R cis-1'R cis isomer of the commercial preparation of atracurium, a mixture of 10 isomers.
It is 3 to 5 times more potent than the mixture with similar onset and duration of action. The single isomer was also reported to have reduced propensity to release histamine
and have a stable cardiovascular profile. Similar to structurally related mivacurium,
cisatracurium has distinct advantages of rapid degradation, enzymatic metabolism that is independent of liver or kidney resulting in short duration of action and fast, complete recovery.
化學的特性
White Solid
使用
Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
定義
ChEBI: The (1R,1'R,2R,2'R)-diastereoisomer of atracurium besylate. Commercial preparations of atracurium are mixtures of 10 stereoisomers, of which cisatracurium generally constitutes about 15%.
isatracurium besylate is about 3 times more potent than the mixture of atracurium isomers as a neuromuscular blocking agent, and is used as a muscle relaxant for endotracheal intubation, to aid controlled ventilation, and in general anaesthesia.
合成
In a work by Yuchen Meng and colleagues[1], 1-(3,4-dimethox-ybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (8) was used as a starting material. R-tetrahydropapaverine (R-6) was generated through a Ru-catalyzed asymmetric transfer hydrogenation reaction with 77.0% yield, 99.45% purity, and 99.67% ee. This was a key step. The control of the chiral nitrogen can be achieved through an N-methylation process to produce (R-cis)-10 with 41.6% yield, 99.08% purity, and gratifying enantio-selectivity (100% de) through a simple and repeatable recrystallization. The process can be utilized to produce Cisatracurium besylate without chromatography purification in five steps with an HPLC purity of 98.71% on a 100-g scale. The process was easy to implement and suitable for manufacturing-scale production.
ベシル酸シサトラクリウム 上流と下流の製品情報
原材料
準備製品
ベシル酸シサトラクリウム 生産企業(yè)
Global( 468)Suppliers
ベシル酸シサトラクリウム スペクトルデータ(1HNMR、MS)
96946-42-8(ベシル酸シサトラクリウム)キーワード:
ベシル酸アトラクリウム
2,2'-[1,5-ペンタンジイルビス[オキシ(3-オキソ-3,1-プロパンジイル)]]ビス[1-[(3,4-ジメトキシフェニル)メチル]-1,2,3,4-テトラヒドロ-6,7-ジメトキシ-2-メチルイソキノリニウム]
キシナホ酸サルメテロール
ジメトキシジメチルシラン
2-[[[[(4-メトキシ-6-メチル-1,3,5-トリアジン-2-イル)(メチル)アミノ]カルボニル]アミノ]スルホニル]安息香酸メチル
2,6-ジメトキシベンズアルデヒド
ジメトキシジフェニルシラン
ジメチルアセタール
ベンゼンスルホニルクロリド
4-ニトロベンゼンスルホニルクロリド
2-クロロプロパン二酸ジメチル
マロン酸ジメチル
イホスファミド
ホルムアルデヒドジメチルアセタール
エタメトスルフロン
3-(3,4-ジヒドロイソキノリン-2(1H)-イル)プロパン-1-オール
(4-メトキシベンジル)(3-メトキシプロピル)アミン HYDROCHLORIDE
ベンジルトリメチルアンモニウムヒドロキシド (40%メタノール溶液)
- 96946-42-8
- (1r,1'r,2r,2'r)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate
- cisatracurium besylate
- 1R-CIS,1R∧-CIS (CISATRACURIUM BESYLATE)
- Cisatrcurium Besylate
- 3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propionic acid 5-[3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl ester
- 5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
- Cisatracurium besyla
- Cisatracurium bes (Cisatracuriumbesylate/Clotrimazole)
- (1R,1'R,2R,2'R)-
- Cis-AttacuriuM
- (1R,1'R)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]-bis[1-[(3,4-diMethoxyphenyl)Methyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl]-isoquinoliniuM dibenzenesulfonate
- 1 kg - 1.5kg
- CisatracuriuM Besilate for Injection
- (1R,1'R,2R,2'R)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium,benzenesulfonate (1:2)
- Cisatracurium besylate (Nimbex)
- Cis-Attacurium besylate
- Cisatracurium besylate ###96946-42-8
- Atracurium Impurity 1（Cisatracurium Besilate）
- Cisatracurium Besylate, cis
- Cisatracurium besilate CRS
- Cisatracurium besyL
- (1R,1'R,2R,2'R)-2,2'-((pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) benzenesulfonate
- Cisatracurium besylate USP/EP/BP
- Cisatracurium Besylate (51W89)
- Cisatracurium besilate (Y0001766)
- Cisatracurium besylateQ: What is
Cisatracurium besylate Q: What is the CAS Number of
Cisatracurium besylate Q: What is the storage condition of
Cisatracurium besylate Q: What are the applications of
Cisatracurium besylate
- Mikhail Zayats
- Cisatracurium Besylate (1134118)
- Benzenesulfonate atracuride
- 2,2′-[Pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]]bis[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]dibenzenesulfonate
- ベシル酸シサトラクリウム
- ベシル酸シサトラクリウム (?90%)