18-(tert-ブトキシ)-18-オキソオクタデカン酸
18-(tert-ブトキシ)-18-オキソオクタデカン酸 物理性質(zhì)
- 融點(diǎn) :
- 68 °C
- 沸點(diǎn) :
- 470.7±18.0 °C(Predicted)
- 比重(密度) :
- 0.950±0.06 g/cm3(Predicted)
- 貯蔵溫度 :
- Sealed in dry,Room Temperature
- 溶解性:
- DMSO（微量）、メタノール（微量）
- 酸解離定數(shù)(Pka):
- 4.78±0.10(Predicted)
- 外見 :
- 個(gè)體
- 色:
- ホワイトからオフホワイト
- InChI:
- InChI=1S/C22H42O4/c1-22(2,3)26-21(25)19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20(23)24/h4-19H2,1-3H3,(H,23,24)
- InChIKey:
- WDUQJXKBWRNMKI-UHFFFAOYSA-N
- SMILES:
- C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCC(O)=O
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報(bào) |
| コード |
危険有害性情報(bào) |
危険有害性クラス |
區(qū)分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
 |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強(qiáng)い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
|
| 注意書き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時(shí)に、飲食または喫煙をしないこ と。 |
| P280 |
保護(hù)手袋/保護(hù)衣/保護(hù)眼鏡/保護(hù)面を著用するこ と。 |
| P302+P352 |
皮膚に付著した場(chǎng)合：多量の水と石鹸で洗うこと。 |
| P305+P351+P338 |
眼に入った場(chǎng)合：水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場(chǎng)合は外す こと。その後も洗浄を続けること。 |
| P332+P313 |
皮膚刺激が生じた場(chǎng)合：醫(yī)師の診斷/手當(dāng)てを受けるこ と。 |
| P337+P313 |
眼の刺激が続く場(chǎng)合：醫(yī)師の診斷/手當(dāng)てを受けること。 |
| P405 |
施錠して保管すること。 |
| P501 |
內(nèi)容物/容器を．．．に廃棄すること。 |
|
18-(tert-ブトキシ)-18-オキソオクタデカン酸 価格
もっと(14)
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQC-8218 |
Octadecanedioic acid mono-tert-butyl ester |
843666-40-0 |
100g |
￥310000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01APOOR303231 |
18-(tert-Butoxy)-18-oxooctadecanoic acid |
843666-40-0 |
1g |
￥4800 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQC-8218 |
Octadecanedioic acid mono-tert-butyl ester |
843666-40-0 |
10g |
￥76500 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01COBQC-8218 |
Octadecanedioic acid mono-tert-butyl ester |
843666-40-0 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01MAS089151 |
18-(tert-Butoxy)-18-oxooctadecanoic acid |
843666-40-0 |
1g |
￥167900 |
2024-03-01 |
購入 |
18-(tert-ブトキシ)-18-オキソオクタデカン酸 化學(xué)特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結(jié)晶
説明
Octadecanedioic acid mono-tert-butyl ester is a non-cleavable ADC linker or alkyl chain-based PROTAC linker for the synthesis of antibody-drug couplings (ADCs) and PROTACs.
使用
18-(tert-Butoxy)-18-oxooctadecanoic Acid is a synthetic intermediate used in the preparation of semaglutide. It can be produced by the catalysis of 18-hydroxyoctadecanoic acid by ethyl bromoacetate in the presence of formamide and magnetic trifluoroacetic acid.
主な応用
18-(tert-Butoxy)-18-oxooctadecanoic acid) is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be reacted with alcohols or amines, while the tert-butyl ester can be deprotected and further connected to another molecule. It is a pharmaceutical intermediate ingredient used in the preparation of somatostatin. It also has catalytic activity.
危険性
18-(tert-butoxy)-18-oxooctadecanoic acid is irritating to humans. Exposure may cause skin, respiratory tract and severe eye irritation. Harmful if swallowed.
合成
A suspension of octadecanedioic Acid (15 g, 47.7 mmol) in Toluene (191 ml) was brought to reflux in 3 neck 1 L round bottom flask. When all the Acid was in solution, 1,1 -di-tert-butoxy-N, N-dimethylmethanamine (22.87 ml, 95 mmol) was added dropwise over 30 minutes. The reaction mixture was heated under reflux overnight. The reaction was stopped after 20 total hours of heating. The reaction mixture was cooled to room temperature, resulting in solid precipitation. The mixture was filtered by vacuum filtration. The resulting white solid was suspended in 200 ml dichloromethane and stirred for 15 minutes. The remaining solids were removed via vacuum filtration. The collected solids were again suspended in dichloromethane and stirred for 15 minutes. After a second filtration, the combined filtrates were concentrated in vacuo, and the resulting white powder 18-(tert-Butoxy)-18-oxooctadecanoic Acid was dried undervacuum.
18-(tert-ブトキシ)-18-オキソオクタデカン酸 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
18-(tert-ブトキシ)-18-オキソオクタデカン酸 生産企業(yè)
Global( 435)Suppliers
| 名前 |
電話番號(hào) |
電子メール |
國籍 |
製品カタログ |
優(yōu)位度 |
|
Suzhou Highfine Biotech Co.,Ltd.
|
+86-0512-68071238 +86-13771819922
|
june@highfine.com |
China |
491 |
58 |
|
SyncoZymes (Shanghai) Co., Ltd.,
|
+86-13681683526（Wechat）
|
lchen@syncozymes.com |
China |
286 |
58 |
|
XIAMEN SINOPEG BIOTECH CO., LTD.
|
+86-0592-7761068 15616186207
|
changaiwei@sinopeg.com |
China |
1133 |
58 |
|
Suzhou Nordica Biopharma CO.,LTD
|
+86-18136148818 +86-18567353071
|
3537297702@qq.com |
China |
299 |
58 |
|
BJV BIOTECH LTD
|
+86-0755-23089946 +86-19006605307
|
bjvbiotech@163.com |
China |
67 |
58 |
|
Chengdu ZY Biochemical Technology Co., Ltd.
|
+86-86-2888626688 18328376625
|
xuehaiying@zybiochem.com |
China |
177 |
58 |
|
Shandong Juntai Pharmaceutical Co. , Ltd.
|
+86-18963498209
|
sales@h2opharm.com |
China |
189 |
58 |
|
Dingwang Technology (Wuhan) Co., Ltd.
|
+undefined-27-2786652399 +undefined13627115097
|
market02@senwayer.com |
China |
887 |
58 |
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
13343047651
|
admin@zlchemi.com |
China |
3692 |
58 |
|
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
|
+86-15350851019; +86-15383190639
|
admin@86-ss.com |
China |
999 |
58 |
18-(tert-ブトキシ)-18-オキソオクタデカン酸 スペクトルデータ(1HNMR、FT-IR)
843666-40-0(18-(tert-ブトキシ)-18-オキソオクタデカン酸)キーワード:
- 843666-40-0
- OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER
- 18-(tert-Butoxy)
- tert-butyl 17-carboxyheptadecanoate
- mono-t-Butyl stearate
- tert-Butyl Hydrogen Octadecanedioate
- Mono-tert-butyl Octadecanedioate
- Boc-C16-COOH
- TIANFUCHEM--843666-40-0---C22H42O4
- 18-[(2-Methyl-2-propanyl)oxy]-18-oxooctadecanoic acid
- 18-(tert-Butoxy)-18-oxostearic acid, tert-Butyl 17-carboxyheptadecanoate
- Octadecanedioic acid 1-tert-butyl ester
- Octadecanedioic acid mono(1,1-dimethylethyl) ester
- Octadecanedioic acid mono-t-butyl ester
- Octadecanedioic acid mono-tert‐butyl ester/ Semaglutide side chain
- 1-(1,1-Dimethylethyl) octadecanedioate
- Antibody-drug conjugates linkers,Boc-C-16-COOH,ADC Linkers,Inhibitor,Boc C16 COOH,BocC16COOH,inhibit,PROTAC Linkers
- Octadecanedioic acid, 1-(1,1-dimethylethyl) ester (ACI)
- cotadecanedioic acid mono-tert-butyl ester
- 18-(tert-Butoxy)-18-oxostearic acid
- ButOOC-C16-COOH
- Octadecanedioic acid mono-t
- (tBu)-Octadecanedioate
- 18-(tert-Butoxy)-18-oxooctadecanoic acid 96%
- Octadecandioic acid mono-tert-butyl ester
- methylpropan-2-yl)oxy]-18-oxooctadecanoic acid
- (S)-2-amino-pentanedioic acid 1,5-di-tert-butyl ester
- 18-(tert-Butoxy)-18-oxooxtadecanoic Acid
- -18-oxooctadecanoic acid
- 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid
- 18-(tert-Butoxy)-18-oxooctadecanoic acid
- 18-(tert-ブトキシ)-18-オキソオクタデカン酸