N-[4-(4-メチルピペラジノメチル)-3-(トリフルオロメチル)フェニル]-4-メチル-3-(1H-ピラゾロ[3,4-b]ピリジン-5-イルエチニル)ベンズアミド 価格

メーカー	製品番號(hào)	製品説明	CAS番號(hào)	包裝	価格	更新時(shí)間	購(gòu)入

N-[4-(4-メチルピペラジノメチル)-3-(トリフルオロメチル)フェニル]-4-メチル-3-(1H-ピラゾロ[3,4-b]ピリジン-5-イルエチニル)ベンズアミド 化學(xué)特性,用途語(yǔ),生産方法

説明

GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC₅₀s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/Abl^T315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC₅₀s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.

使用

GZD824 is a orally bioavailable inhibitor that targets phosphorylated and non-phosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) kinases. It is a COVID19-related research product.

合成

In a recent patent, the synthesis of olverembatinib began with a Sonogashira coupling reaction of commercially available alkyne 24.1 with pyridinium bromide 24.2 to afford ester 24.3 in 98% yield. The N-Boc group of carbonate 24.3 was cleaved by refluxing in a mixture of MeOH and water to afford pyrazole 24.4 in 91% yield. Finally, potassium tert-butoxide-mediated amide formation with aniline 24.5 afforded olverembatinib (24) in 88% yield.

target

BCR-ABL

N-[4-(4-メチルピペラジノメチル)-3-(トリフルオロメチル)フェニル]-4-メチル-3-(1H-ピラゾロ[3,4-b]ピリジン-5-イルエチニル)ベンズアミド 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

N-[4-(4-メチルピペラジノメチル)-3-(トリフルオロメチル)フェニル]-4-メチル-3-(1H-ピラゾロ[3,4-b]ピリジン-5-イルエチニル)ベンズアミド 生産企業(yè)

名前	電話番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TianYuan Pharmaceutical CO.,LTD	+86-755-23284190 13684996853	sales@tianpharm.com	CHINA	304	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21193	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32468	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30224	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29093	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

1257628-77-5(N-[4-(4-メチルピペラジノメチル)-3-(トリフルオロメチル)フェニル]-4-メチル-3-(1H-ピラゾロ[3,4-b]ピリジン-5-イルエチニル)ベンズアミド)キーワード:

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• 1257628-77-5
• 4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
• 3-(2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
• GZD8824
• GZD824;GZD-824;GZD 824
• GZD-824 Free
• GZD 824
• GZD-824; GZD 824;BENZAMIDE
• Benzamide, 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-
• GZD 824 USP/EP/BP
• 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
• Olverembatinib
• Olverembatinib (GZD824)
• 3-[(1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide
• 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{1H-pyrazolo[3,4-b]pyridin-5-yl}ethynyl)benzamide
• Olverembatinib, 10 mM in DMSO
• GZD824
• GZD-824
• N-[4-(4-メチルピペラジノメチル)-3-(トリフルオロメチル)フェニル]-4-メチル-3-(1H-ピラゾロ[3,4-b]ピリジン-5-イルエチニル)ベンズアミド
• 4-メチル-N-{4-[(4-メチルピペラジン-1-イル)メチル]-3-(トリフルオロメチル)フェニル}-3-(2-{1H-ピラゾロ[3,4-b]ピリジン-5-イル}エチニル)ベンズアミド