TH287 価格 もっと(3)

メーカー	製品番號(hào)	製品説明	CAS番號(hào)	包裝	価格	更新時(shí)間	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01COBQJ-0655	6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine	1609960-30-6	100mg	￥350000	2024-03-01	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01COBQJ-0655	6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine	1609960-30-6	500mg	￥972000	2023-06-01	購(gòu)入
Sigma-Aldrich Japan	SML1069	≥98% (HPLC) TH287 hydrochloride ≥98% (HPLC)	1609960-30-6	5mg	￥20500	2024-03-01	購(gòu)入

TH287 化學(xué)特性,用途語(yǔ),生産方法

説明

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC₅₀ = 0.8 nM) that selectively kills cancer cell lines (IC₅₀s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC₅₀s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).

使用

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.

TH287 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

TH287 生産企業(yè)

名前	電話番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32466	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10457	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11680	58
Wuhan Topule Biopharmaceutical Co., Ltd	+86-18327326525	masar@topule.com	China	8467	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9942	58

1609960-30-6()キーワード:

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• 1609960-30-6
• TH287 hydrochloride
• TH287
• 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
• 6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride
• 6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
• TH287;TH-287
• CS-1671
• TH287, >98%
• 2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-
• 6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine
• Centicin
• Oksitselanim
• Septigen
• 6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine , TH287
• TH287, 10 mM in DMSO
• TH287 ，S7631