ML-3000
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- CAS番號(hào).
- 156897-06-2
- 化學(xué)名:
- ML-3000
- 別名:
- 6-(4-クロロフェニル)-7-フェニル-2,2-ジメチル-2,3-ジヒドロ-1H-ピロリザイン-5-酢酸;2-[6-(4-クロロフェニル)-2,2-ジメチル-7-フェニル-2,3-ジヒドロ-1H-ピロリジン-5-イル]酢酸;6-(4-クロロフェニル)-2,2-ジメチル-7-フェニル-2,3-ジヒドロ-1H-ピロリザイン-5-酢酸;ML-3000
- 英語名:
- Licofelone
- 英語別名:
- icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;Licofelone, 10 mM in DMSO;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-
- CBNumber:
- CB91385206
- 化學(xué)式:
- C23H22ClNO2
- 分子量:
- 379.88
- MOL File:
- 156897-06-2.mol
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ML-3000 物理性質(zhì)
- 融點(diǎn) :
- 162-163°C
- 沸點(diǎn) :
- 539.7±50.0 °C(Predicted)
- 比重(密度) :
- 1.23
- 貯蔵溫度 :
- -20°C Freezer
- 溶解性:
- クロロホルム、メタノール
- 酸解離定數(shù)(Pka):
- 4.47±0.10(Predicted)
- 外見 :
- 個(gè)體
- 色:
- オフホワイトからライトイエロー
- CAS データベース:
- 156897-06-2(CAS DataBase Reference)
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
ML-3000 価格
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購入 |
ML-3000 化學(xué)特性,用途語,生産方法
説明
Cross-
talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-
1β (IL-
1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E
2, leukotriene B
4, and lipoxins and prevents lipopolysaccharide-
stimulated IL-
1β expression. The IC
50 values for inhibition of human thrombocyte COX and human 5-
LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-
steroidal anti-
inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-
secretory mechanisms, mediated by the inhibition of 5-
LO activity.
化學(xué)的特性
Yellowish Solid
ML-3000 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
ML-3000 生産企業(yè)
Global( 154)Suppliers
156897-06-2(ML-3000)キーワード:
- 156897-06-2
- 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
- Licofelone, ML-3000
- [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
- ML 3000
- 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
- Licofelone
- 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
- 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-
- Licofelone, >=99%
- icofeL
- Licofelone USP/EP/BP
- 16-dihydrotanshinone I
- Licofelone, 10 mM in DMSO
- 6-(4-クロロフェニル)-7-フェニル-2,2-ジメチル-2,3-ジヒドロ-1H-ピロリザイン-5-酢酸
- 2-[6-(4-クロロフェニル)-2,2-ジメチル-7-フェニル-2,3-ジヒドロ-1H-ピロリジン-5-イル]酢酸
- 6-(4-クロロフェニル)-2,2-ジメチル-7-フェニル-2,3-ジヒドロ-1H-ピロリザイン-5-酢酸
- ML-3000