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N-(3-??????)????

N-(3-??????)????
N-(3-??????)???? ??? ???
?? ??:
7357-67-7
???:
N-(3-??????)????
???(??):
N-(3-??????)????
???:
4-(3-Chloropropyl)morpholine
???(??):
N-(3-Chloropropyl)morpholine;Gefitinib iMpurity A;4-(3-ChL;NSC 38889;NSC 28831;)-morphoL;N-(3-Chloropropyl)M;IFLAB-BB F2108-0002;Gefitinib IMpurity VI;Gefitinib Impurity 81
CBNumber:
CB0240217
???:
C7H14ClNO
??? ??:
163.65
MOL ??:
7357-67-7.mol

N-(3-??????)???? ??

???
NA
?? ?
115°C/25mmHg(lit.)
??
1.0409 g/cm3
RTECS ??
QE0488000
???
1.4720-1.4760
???
91 °C
?? ??
Inert atmosphere,Store in freezer, under -20°C
???
?????(?? ???), ???(?? ???)
??? ??
??
?? ?? (pKa)
7.03±0.10(Predicted)
Specific Gravity
1.08
??
??~??
InChI
InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
InChIKey
PQECODMSWJOUAT-UHFFFAOYSA-N
SMILES
N1(CCCCl)CCOCC1
CAS ??????
7357-67-7(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
?? ???? ?? 36/37/38
????? 26-36/37/39
?? ?? IRRITANT
HS ?? 2934999090
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
NFPA 704
0
2 0

N-(3-??????)???? C??? ??, ??, ??

??

4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes.

??? ??

Pale Yellow Oil

?? ??

4-(3-Chloropropyl)morpholine is an organic synthetic reagent or pharmaceutical intermediate used in the synthesis of gefitinib. It has cancer-inhibiting properties and inhibits epidermal growth factor (EGF). It also inhibits cell proliferation by inhibiting DNA synthesis.

N-(3-??????)???? ?? ?? ? ???

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N-(3-??????)???? ?? ??

???( 372)?? ??
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N-(3-??????)???? ?? ??:

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