ZONIPORIDE
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ZONIPORIDE ??
- ??
- 1.54
- ?? ??
- 2-8°C
- ???
- H2O: ???2mg/mL, ??(???)
- ??? ??
- ??
- ?? ?? (pKa)
- 11.44±0.46(Predicted)
- ??
- ???? ?????
- ???
- H2O: 2mg/mL, clear (warmed)
- InChI
- 1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
- InChIKey
- UCIJUEGJEFJRMP-UHFFFAOYSA-N
- SMILES
- O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| WGK ?? | 3 | ||
|---|---|---|---|
| ???? ??? | 11 - Combustible Solids |
| ????(GHS): |
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| ?? ?: | Danger | ||||||||||||||||
| ??·?? ??: |
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| ??????: |
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ZONIPORIDE C??? ??, ??, ??
??
Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.Biochem/physiol Actions
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.ZONIPORIDE ?? ?? ? ???
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?? ??
ZONIPORIDE ?? ??
???( 34)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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