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ChemicalBook CAS DataBase List N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)
1146618-41-8

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) synthesis

3synthesis methods
Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: hydrogenchloride / water / 5.87 h / 20 °C
2.1: bromine / acetic acid / 3.93 h / 50 - 55 °C
3.1: ethanol; water / 3.17 h / 78 °C
4.1: triethylamine / acetonitrile / 2.25 h / 54.5 °C
4.2: 5.38 h / 50 °C
5.1: acetic acid / 1.65 h / 60 - 65 °C

References:

SUNESIS PHARMACEUTICALS, INC. WO2009/114856, 2009, A2

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Related Search:

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