ChemicalBook >?? ???? >??? ??>???>?????>?? - ??? ?? ? ???>cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid ??? ???

?? ??:: 471905-41-6

???:: cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

???(??):: CS-10;MK-0752/MK0752;MK-0752, >=98%;MK-0752, 10 mM in DMSO;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid;3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid MK-0752;Aβ40,MK 0752,inhibit,barrier,γ-secretase,blood-brain,Inhibitor,MK-0752,CNS,MK0752,Gamma secretase

CBNumber:: CB02521129

???:: C21H21ClF2O4S

??? ??:: 442.9

MOL ??:: 471905-41-6.mol

?? ?? 119

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid ??

???: 166.6-167.5 °C(Solv: isopropyl acetate (108-21-4); heptane (142-82-5))

?? ?: 616.9±55.0 °C(Predicted)

??: 1.361

?? ??: Store at -20°C

???: ≥22.15 mg/mL in DMSO; insoluble in H2O; ≥48.8 mg/mL in EtOH with ultrasonic

??? ??: ??

?? ?? (pKa): 4.76±0.10(Predicted)

??: White to off-white

InChI: InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)/t14-,21-

InChIKey: XCGJIFAKUZNNOR-HNSKJHPRSA-N

SMILES: [C@@H]1(CCC(O)=O)CC[C@](S(C2=CC=C(Cl)C=C2)(=O)=O)(C2=CC(F)=CC=C2F)CC1

?? ? ?? ??
?? ? ???? ?? (GHS)

HS ??	29163990

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H317	????? ?? ??? ??? ? ??	?? ??? ??	?? 1	??		P261, P272, P280, P302+P352,P333+P313, P321, P363, P501

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P272	??? ??? ??? ??? ???? ???.
P280	????/???/???/?????? ?????.
P302+P352	??? ??? ??? ?? ????.
P333+P313	????? ?? ??? ???? ???? ??·??? ????.
P501	...? ??? / ??? ?? ???.

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid C??? ??, ??, ??

??

γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells with an IC50 value of 5 nM. It is orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys. Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel in mice with breast cancer tumors.[Cayman Chemical]

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid ?? ?? ? ???

???

3-((1s,4r)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanal 2-(1-(4-????????)??)-1,4-??????? 2-((4-????????)??)-1,4-??????? 2,5-Difluorobenzyl bromide 4-(4-????????)-4-(2,5-???????)?????? (4-?????)(2,5-???????)?? 4-Chlorothiophenol ???? ??????

?? ??

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid ?? ??

???( 119)?? ??

???	??	???	??	?? ?	??
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cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid ?? ??:

4-Chloroaniline Chlorobenzene Semagacestat DAPT Avagacestat (BMS-708163) LY411575 RO4929097 DIBENZAZEPINE

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