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STA 21

STA 21 ??? ???
?? ??:
111540-00-2
???:
STA 21
???(??):
STA 21;STA-21(b);(Rac)-STA-21;STA-21 >=95% (HPLC);Ochromycinone (STA-21);Ochromycinone, 10 mM in DMSO;8-Hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione;8-Hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione[STA21;8-HYDROXY-3-METHYL-1,2,3,4,7,12-HEXAHYDROTETRAPHENE-1,7,12-TRIONE;Benz[a]anthracene-1,7,12(2H)-trione, 3,4-dihydro-8-hydroxy-3-methyl-
CBNumber:
CB02667450
???:
C19H14O4
??? ??:
306.31
MOL ??:
111540-00-2.mol
MSDS ??:
SDS

STA 21 ??

?? ?
568.6±50.0 °C(Predicted)
??
1.387±0.06 g/cm3(Predicted)
?? ??
Store at -20°C
???
DMSO? ???
??? ??
??? ??
?? ?? (pKa)
6.61±0.40(Predicted)
??
Light yellow to yellow
InChI
1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3
InChIKey
ZAWXOCUFQSQDJS-UHFFFAOYSA-N
SMILES
CC1CC(C(C(C(C(C=CC=C2O)=C2C3=O)=O)=C3C=C4)=C4C1)=O

??

WGK ?? WGK 3
???? ??? 11 - Combustible Solids

STA 21 C??? ??, ??, ??

??

STA 21 selectively inhibits signal transducers and activators of transcription 3 (Stat3), which is transcription factor that is often found to be constitutively active in human breast cancer (1). It also inhibits osteoclastogenesis in mice and humans (2). In addition, STA 21 has been shown to attenuates the development and progression of inflammation in collagen antibody-induced arthritis and therefore, this compound may be used to develop therapeutic strategies to treat rheumatoid arthritis (3).

STA 21 ?? ?? ? ???

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STA 21 ?? ??

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