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?? ???? >1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ??? ???
?? ??:
2098457-92-0
???:
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
???(??):
Apixaban Impurity 3;BMS-778960;Apixaban-7;BMS-591455-01;Impurity of apixaban377;Apixaban ImpurityMS-778960-01;Apixaban Impurity 13 (BMS-778960-01);1-(4-methoxyphenyl)-6-[4-(2-methyl-6-oxopiperidin-1-yl)phenyl]-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide;1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide;1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-[4-(2-methyl-6-oxo-1-piperidinyl)phenyl]-7-oxo-
CBNumber:
CB02681131
???:
C26H27N5O4
??? ??:
473.52
MOL ??:
2098457-92-0.mol
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ??
?? ?
766.0±60.0 °C(Predicted)
??
1.39±0.1 g/cm3(Predicted)
?? ?? (pKa)
15.01±0.20(Predicted)
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?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
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P- ??
H302 ??? ???
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?? 4
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P264, P270, P301+P312, P330, P501
H315 ??? ??? ???
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?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
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P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ??
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?? 3
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??????:
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide C??? ??, ??, ??
??
1-(4-Methoxyphenyl)-6-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ?? ?? ? ???
???
?? ??
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ?? ??
???( 76)?? ??
China 70
India 3
United States 3
Global 76
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ?? ??:
ethyl 6-(4-(5-chloropentanaMido)phenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
Apixaban IMpurity 6
Apixaban IMpurity 3
(4,4'‐didodecyl‐2,2'‐
bithiophene‐5,5'‐
diyl)bis(triMethylstann
ane)
Apixaban IMpurity 2
Apixaban IMpurity 5 (BMS-591329-01)
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE
Apixaban Impurity 13
Butanoic acid, 2-[(4-hydroxyphenyl)hydrazono]-3-oxo-, ethyl ester
Apixaban Impurity 34
Apixaban Impurity 15
