Selonsertib
|
|
Selonsertib ??
- ???
- >180°C (dec.)
- ??
- 1.39±0.1 g/cm3(Predicted)
- ?? ??
- -20°C
- ???
- DMSO? ???(>25mg/ml)
- ?? ?? (pKa)
- 11.21±0.70(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???
- ???
- ??? ?? ?????? 2? ?? ??????. DMSO ??? -20°C?? ?? 3?? ?? ??? ? ????.
- InChIKey
- YIDDLAAKOYYGJG-UHFFFAOYSA-N
- SMILES
- C(NC1=NC(C2N(C(C)C)C=NN=2)=CC=C1)(=O)C1=CC(N2C=NC(C3CC3)=C2)=C(C)C=C1F
- CAS ??????
- 1448428-04-3
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
Selonsertib C??? ??, ??, ??
??
Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Selonsertib interacts with the catalytic kinase domain of ASK1 and prevents its phosphorylation and activation. As a result, the expression of genes involved in fibrosis, cellular proliferation, and apoptosis are down regulated.Selonsertib ?? ?? ? ???
???
?? ??
Selonsertib ?? ??
???( 158)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29812 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2994 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 |
info@shochem.com | CHINA | 288 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 |
info@chemia-pharm.com | CHINA | 311 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 |
sales@shengdapharm.com | CHINA | 310 | 58 |
Selonsertib ?? ??:
GSK-114
GSK-626616
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
Presatovir
4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE
S-Ruxolitinib (INCB018424)
Tofacitinib
GDC-0084
SH-4-54
Osimertinib mesylate
Niraparib
Mertansine
Enasidenib
Ivosidenib
ABBV-075
(+)-JQ-1
Tazemetostat
Selpercatinib