ANTI-CD56
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ANTI-CD56 ??
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- -20°C
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- mouse
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| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 21/22-22 | ||
| ????? | 36/37 | ||
| WGK ?? | 3 | ||
| ???? ??? | 12 - Non Combustible Liquids |
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Monoclonal Anti-HNK-1/N-CAM (CD57) antibody produced in mouse has been used:- as primary antibody for western blot analysis
- immunocytochemistry
- immunocytochemical
- immunohistological staining
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Monoclonal Anti-HNK-1/N-CAM (CD57) (mouse IgM isotype) is derived from the VC1.1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Human natural killer cell -1 (HNK-1), also referred as B3GAT1, NK1, CD57, LEU7, NK-1, GLCATP and GLCUATP, is mapped to human chromosome 11q25. The encoded protein belongs to the glucuronyltransferase gene family. Neural cell-adhesion molecule (N-CAM) is expressed on all neuroepithelial cells from the time of neural induction in the early embryo. It is known that the sulfated carbohydrate HNK-1 epitope is carried by several surface molecules including a proportion of N-CAM isoforms.Biochem/physiol Actions
HNK1 (human natural killer-1) is referred as B3GAT1, NK1, CD57, LEU7, NK-1, GLCATP and GLCUATP. It is a member of the glucuronyltransferase gene family. Human natural killer-1 (HNK1) carbohydrate epitope is expressed on various cell adhesion molecules in the nervous system and plays a role in cell-cell and cell-substrate interactions. HNK-1 epitope stabilizes GluR2 on neuronal surface membranes and regulates cell surface stability of GluR2 by modulating the interaction with N-cadherin. It is also plays a role in cell migration and synaptic plasticity. HNK-1 epitope has been associated with the risk of metastasis. It is observed to be highly expressed in melanoma cell lines.ANTI-CD56 ?? ?? ? ???
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