Doripenem hydrate
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Doripenem hydrate ??
- ???
- 173°C(dec.)(lit.)
- ?? ??
- 2-8°C
- ???
- H2O: ???5mg/mL, ??(???)
- ??? ??
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- ???? ????
- ??????(pH)
- Dissolve 0.3g of Doripenem Hydrate in 30mL of water: the pH of the solution is between 4.5 and 6.0.
- ???
- H2O: 5mg/mL, clear (warmed)
- BRN
- 15340136
- InChIKey
- NTUBEBXBDGKBTJ-WGLOMNHJSA-N
- SMILES
- C(C1=C([C@H](C)[C@]2([H])[C@@]([H])([C@H](O)C)C(=O)N12)S[C@@H]1CN[C@H](CNS(=O)(=O)N)C1)(=O)O.O |&1:3,5,7,9,16,19,r|
- CAS ??????
- 364622-82-2(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| WGK ?? | 3 | ||
|---|---|---|---|
| HS ?? | 2935.90.9500 | ||
| ???? ??? | 11 - Combustible Solids |
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| ?? ?: | Warning | ||||||||||||||
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Doripenem hydrate C??? ??, ??, ??
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Doripenem hydrate is a carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.Doripenem hydrate was first approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on July 25, 2005, then approved by the U.S. Food and Drug Administration (FDA) on Oct 12, 2007, and approved by European Medicines Agency (EMA) on July 25, 2008. It was developed by Shionogi and Janssen, then marketed as Finibax® in Japan and as Doribax® in the US by Shionogi and as Doribax® by Janssen in BE.
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Doripenem Hydrate occurs as a white to pale yellow-brown-white crystalline powder. It is sparingly soluble in water, slightly soluble in methanol, and practically insoluble in ethanol (99.5). It is gradually colored to pale yellow-brown-white by light.??
Doripenem (doripenem monohydrate) is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It is particularly active against Pseudomonas aeruginosaBiochem/physiol Actions
Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria.Doripenem hydrate ?? ?? ? ???
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(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
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Doripenem hydrate ?? ??
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|---|---|---|---|---|---|
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Doripenem hydrate ?? ??:
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Doripenem
Tyrphostin AG 490
(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
Meropenem
ACS-PNZ-PYRROLIDYL-(BOC)-NSO2NH2
BIAPENEM SIDE CHAIN
3-[(2S,4S)-4-Mercaptopyrrolidine-2-carboxamido]benzoic acid hydrochloride
3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid
Ertapenem sodium
Side chain for meropenem
Biapenem
Rosuvastatin calcium
GOSSYPOL
Temozolomide
Thienamycin
Doripenem hydrate